[HTML][HTML] Accumulation of copy number alterations and clinical progression across advanced prostate cancer
E Grist, S Friedrich, C Brawley, L Mendes, M Parry… - Genome Medicine, 2022 - Springer
… recurrence and death from prostate cancer [4, 5, 10]. … burden of copy number alteration is
non-linearly associated with risk of clinical progression and death in advanced prostate cancer, …
non-linearly associated with risk of clinical progression and death in advanced prostate cancer, …
[HTML][HTML] Tumor copy number alteration burden is a pan-cancer prognostic factor associated with recurrence and death
… if CNA burden can predict outcome of other types of cancers. … The copy number alteration
landscape of the conservative … revealed canonical copy number alterations of prostate cancer, …
landscape of the conservative … revealed canonical copy number alterations of prostate cancer, …
A DNA copy number alteration classifier as a prognostic tool for prostate cancer patients
W Ebrahimizadeh, KP Guérard, S Rouzbeh… - … Journal of Cancer, 2023 - nature.com
… with low or intermediate risk of relapse. Several somatic DNA … hazard modelling to predict
biochemical recurrence. … Combinations of specific CNAs, as well as global CNA burden (…
biochemical recurrence. … Combinations of specific CNAs, as well as global CNA burden (…
[HTML][HTML] Exome sequencing identified six copy number variations as a prediction model for recurrence of primary prostate cancers with distinctive prognosis
J Liu, J Yan, R Mao, G Ren, X Liu, Y Zhang… - Translational Cancer …, 2020 - ncbi.nlm.nih.gov
… based model can correctly predict 73% of relapsed cases and 75% … recurrent regions of
genomic loss and gain, and confirmed that the burden of SCNAs (somatic copy number alteration…
genomic loss and gain, and confirmed that the burden of SCNAs (somatic copy number alteration…
[HTML][HTML] Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer
J Fernandez-Mateos, GD Cresswell, N Trahearn… - Nature Cancer, 2024 - nature.com
… We found a significantly increased burden of CNAs at relapse, with high PGA levels (Fig.
3e)… We then used the copy number profiles to add the recurrent sample to the phylogenetic …
3e)… We then used the copy number profiles to add the recurrent sample to the phylogenetic …
Copy number alterations are associated with metastatic-lethal progression in prostate cancer
X Wang, CS Grasso, KM Jordahl, S Kolb… - … cancer and prostatic …, 2020 - nature.com
… We detected 15 recurrent CNAs were associated with … c ROC curves for predicting
metastatic-lethal prostate cancer … d ROC curves for predicting metastatic-lethal prostate cancer …
metastatic-lethal prostate cancer … d ROC curves for predicting metastatic-lethal prostate cancer …
[HTML][HTML] Genomic alteration burden in advanced prostate cancer and therapeutic implications
… how a tumor's mutation burden may help predict response to … However, copy number
alterations (CNA) of individual genes … with respect to biochemical relapse following definitive …
alterations (CNA) of individual genes … with respect to biochemical relapse following definitive …
[HTML][HTML] Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data
…, CRUK-ICGC Prostate Group… - PLoS …, 2017 - journals.plos.org
… recurrent somatic copy number alteration (SCNA) in human … that the burden of SCNAs is
predictive of biochemical recurrence, … prediction of 5-year biochemical recurrence of prostate …
predictive of biochemical recurrence, … prediction of 5-year biochemical recurrence of prostate …
Acquired copy number variation in prostate tumours: a review of common somatic copy number alterations, how they are formed and their clinical utility
… prognostic tests that accurately predict disease course; however, … (SCNA) correlates with
more aggressive disease, recurrence … 1: Somatic copy number alterations in prostate cancer …
more aggressive disease, recurrence … 1: Somatic copy number alterations in prostate cancer …
[HTML][HTML] Mutational load of the mitochondrial genome predicts pathological features and biochemical recurrence in prostate cancer
AMF Kalsbeek, EFK Chan, J Grogan… - Aging (Albany …, 2016 - ncbi.nlm.nih.gov
… for prostate cancer, we determined the power of total mtDNA variation burden to predict
disease relapse in … The unique properties of mtDNA including its small size, high copy number, …
disease relapse in … The unique properties of mtDNA including its small size, high copy number, …