Corneal confocal microscopy to image small nerve fiber degeneration: ophthalmology meets neurology

IN Petropoulos, G Bitirgen, M Ferdousi… - Frontiers in Pain …, 2021 - frontiersin.org
… we have shown that corneal nerve loss occurs in patients with … inferior whorl corneal nerve
fiber length has been found in … the directional symmetry coefficient of corneal nerve fibers has …

Corneal nerve and epithelial cell alterations in corneal allodynia: an in vivo confocal microscopy case series

P Hamrah, Y Qazi, B Shahatit, MH Dastjerdi… - The ocular …, 2017 - Elsevier
… compares the corneal nerve morphometrics for both eyes in patients with symmetric disease.
… Earlier, we found a similar loss in corneal subbasal nerve length and branch numbers with …

Relationship between corneal confocal microscopy and markers of peripheral nerve structure and function in Type 2 diabetes

A Yan, T Issar, SS Tummanapalli, M Markoulli… - Diabetic …, 2020 - Wiley Online Library
corneal nerve measures correlated with increasing neuropathy severity. Associations were
found between corneal confocal microscopysymmetrical progression of corneal nerve loss in …

Corneal confocal microscopy for assessment of diabetic peripheral neuropathy: a meta-analysis

MS Jiang, Y Yuan, ZX Gu, SL Zhuang - British Journal of …, 2016 - bjo.bmj.com
… valuable for detecting and assessing early nerve damage in … (DPN) as a chronic, symmetrical,
length-dependent diabetic … that corneal nerve changes could be detected using CCM in …

Corneal confocal microscopy demonstrates corneal nerve loss in patients with trigeminal neuralgia

JI Lee, T Böcking, D Holle-Lee, RA Malik… - Frontiers in …, 2020 - frontiersin.org
… is a rapid non-invasive imaging technique that identifies symmetrical corneal nerve loss in
… that corneal nerve loss was comparable between TN patients with or without nerve vessel …

In Vivo Confocal Microscopic Evaluation of Corneal Nerve Fibers and Dendritic Cells in Patients With Behçet's Disease

G Bitirgen, E Tinkir Kayitmazbatir, G Satirtav… - Frontiers in …, 2018 - frontiersin.org
… density around the central corneal nerve plexus of patients with … related to disease duration
or corneal nerve parameters. Although this study lacks patients with active uveitis, we found

Corneal confocal microscopy identifies small fibre damage and progression of diabetic neuropathy

S Dhage, M Ferdousi, S Adam, JH Ho, A Kalteniece… - Scientific reports, 2021 - nature.com
… LDIflare, cooling detection thresholds and … nerve damage despite an improvement in
glycaemic control and LDL cholesterol. Furthermore, corneal nerve loss was associated with a loss

Diagnostic utility of corneal confocal microscopy and intra-epidermal nerve fibre density in diabetic neuropathy

U Alam, M Jeziorska, IN Petropoulos, O Asghar… - PloS one, 2017 - journals.plos.org
… III in vivo corneal confocal microscope employing our … (INP) undertook analysis of corneal
nerve morphology. We have … ) early subclinical small nerve fibre loss can be detected by CCM …

Corneal confocal microscopy compared with quantitative sensory testing and nerve conduction for diagnosing and stratifying the severity of diabetic peripheral …

M Ferdousi, A Kalteniece, S Azmi… - BMJ Open Diabetes …, 2020 - drc.bmj.com
… identifies early and progressive corneal nerve loss at the inferior whorl and central cornea and
has … that quantification of corneal nerve morphology at the inferior whorl may detect earlier …

Corneal confocal microscopy detects small nerve fibre damage in patients with painful diabetic neuropathy

A Kalteniece, M Ferdousi, S Azmi, WM Mubita… - Scientific reports, 2020 - nature.com
… In conclusion, we show that corneal confocal microscopy detects greater corneal nerve
fibre loss in patients with painful diabetic neuropathy and this correlates with the severity of …