[HTML][HTML] Liver Fibrosis: From Basic Science towards Clinical Progress, Focusing on the Central Role of Hepatic Stellate Cells

H Akkız, RK Gieseler, A Canbay - International Journal of Molecular …, 2024 - mdpi.com
… In chronic liver disease, a close and potent relationship … In addition, α-SMA and connective
tissue growth factor (CTGF) … and/or by measuring liver stiffness with transient elastography (…

Suppression of the fibrotic encapsulation of silicone implants by inhibiting the mechanical activation of pro-fibrotic TGF-β

N Noskovicova, R Schuster, S van Putten… - Nature Biomedical …, 2021 - nature.com
… and of pro-fibrotic transforming growth factor beta 1 (TGF-β1). … of both integrins were
correlated with the fibroblast activation … that of normal breast connective tissue were less likely to …

Association of adipokines with hepatic steatosis and fibrosis in chronic hepatitis B patients on long‐term nucleoside analogue

LY Mak, CH Lee, KS Cheung, DKH Wong… - Liver …, 2019 - Wiley Online Library
… (NA) with accurate transient elastography measurement, we … causal relationship between
adipokines and CHB-related liver … and protein expression of connective tissue growth factor,50 …

Stiffness and hepatocytes function in vitro

S Kidambi - Liver Elastography: Clinical Use and Interpretation, 2020 - Springer
… Clinical research assessing liver stiffness by transientliver-enriched transcription factors,
including hepatocyte nuclear … stiffness and potential relationship among substrate stiffness, …

A two-dimensional (2d) systems biology-based discrete liver tissue model: A simulation study with implications for ultrasound elastography of liver fibrosis

Y Wang, J Jiang - Computers in biology and medicine, 2019 - Elsevier
… For each model, one transient cycle of plane shear or … correlation length (CL) were calculated
from all microscopic … Table 4 summarizes the liver stiffness values of four METAVIR stages …

Modeling and measuring extracellular matrix alterations in fibrosis: challenges and perspectives for antifibrotic drug discovery

P Sivakumar, C Kitson, G Jarai - Connective tissue research, 2019 - Taylor & Francis
… to tissue homeostasis. Upon injury, components of the ECM transiently activate growth
factors and … growth factor beta1 - an intimate relationship. Eur J Cell Biol 2008;87(8–9):601–615. …

Therapeutic strategies to target connective tissue growth factor in fibrotic lung diseases

T Isshiki, S Naiel, M Vierhout, K Otsubo, P Ali… - Pharmacology & …, 2023 - Elsevier
transient activation of myofibroblasts allows for the generation of contractile forces that
mediates wound closure and production of collagen-rich ECM that provides a scaffold for tissue

[HTML][HTML] Chronic hepatitis C virus infection: Serum biomarkers in predicting liver damage

P Valva, DA Ríos, E De Matteo… - World journal of …, 2016 - ncbi.nlm.nih.gov
… More specifically, TE measures liver stiffness in relation to … process [in particular transforming
growth factor (TGF)-β1]. … major constituent of the connective tissue. During fibrogenesis, …

Transient elastography as a noninvasive assessment tool for hepatopathies of different etiology in pediatric type 1 diabetes mellitus

ZA Elkabbany, NS Elbarbary, EA Ismail… - Journal of Diabetes and …, 2017 - Elsevier
Liver stiffness was positively correlated to HbA1c and ALT. … of chronic infection, connective
tissue disease, celiac disease, … Liver stiffness measurements were done for patients with …

Integrated Study of Liver Fibrosis: Modeling and Clinical Detection

H Chen - 2020 - scholarworks.gsu.edu
… how the liver stiffness affects the blood flow pattern, predicting a direct relationship between
… The ultrasound wave of transient elastography only measures one point of the liver to …