… with increased deacetylated histone 3 (H3) occupancy at Nuc-1. This repressive chromatin
… mixture of multiply infected cells with various HIV integration sites, were used as our model …

… , etc.) that have to be integrated into lineage-specific transcriptional programs leading to the
… , resulting in the deacetylation of histones and a closed chromatin structure. HDACs might …

… integrated provirus is then chromatinized and similarly to cellular genes, post-translational
modifications of histones, such as methylation, acetylation … we assessed occupancy of HDAC1 …

… may integrate into host chromatin under certain conditions. Small molecules targeting catalysis
and recognition of protein acetylation … occupancy, and/or altering the activity of histone-…

… , integration site, and the surrounding chromatin environment. … Histone acetylation is
catalyzed by a group of enzymes … tighter chromatin environment and a loss of RNAPII occupancy …

… initiate chromatin remodeling of the integrated provirus [29,30]. Recruitment of HATs has
been linked to increases in global H3 and H4 acetylation … HDACi histone deacetylase inhibitor …

… following histone deacetylase (… Histone deacetylase inhibitors are widely studied HIV
latency-reversing agents (LRAs). VOR, an HDACi, induces histone acetylation and chromatin …

… integration status of the viral DNA: pre- and post-integration … by increasing deacetylated
histone 3 occupancy at Nuc-1 [91]… while the activating chromatin remodeling complex PBAF was …

… Histone deacetylase (HDAC) inhibitors have been the most … of the population of latent
integrated proviruses suggests the … , vorinostat induces HIV chromatin acetylation and promoter …

… chromatin decondensation and gene expression. In oncology clinical trials, histone acetylation
… In this study, we used a Jurkat 2D10 cell line that contains a single integrated HIV provirus…