Evaluation of sucrose laurate as an intestinal permeation enhancer for macromolecules: ex vivo and in vivo studies

F McCartney, M Rosa, DJ Brayden - Pharmaceutics, 2019 - mdpi.com
… , isolated rat intestinal tissue mucosae, and rat intestinal … increases in paracellular marker
fluxes and TEER reductions with 5 … [62] also compared C 10 with sucrose caprate in promoting

Ex vivo intestinal sacs to assess mucosal permeability in models of gastrointestinal disease

SW Mateer, J Cardona, E Marks, BJ Goggin… - JoVE (Journal of …, 2016 - jove.com
intestinal barrier function in animal models of gastrointestinal … the flux of a paracellular probe
across the mucosal surface at … apparent permeability (P app ) of a marker molecule across

[HTML][HTML] Sodium glycodeoxycholate and sodium deoxycholate as epithelial permeation enhancers: in vitro and ex vivo intestinal and buccal bioassays

DJ Brayden, V Stuettgen - European Journal of Pharmaceutical Sciences, 2021 - Elsevier
… the P app of the paracellular marker, FITC-dextran 4000 (FD4… H]-octreotide flux across isolated
rat colonic mucosae (iv) the … were efficacious at promoting transepithelial peptide flux, but …

Application of cell culture and tissue models for assessing drug transport

CU Nielsen, B Brodin - Analytical Techniques in the Pharmaceutical …, 2016 - Springer
… in terms such as flux, permeability or clearance. Considering the … and their use in investigating
intestinal permeability, drug-… to the presence of the mucus layer in the in vivo situation. …

Exposure to a nonionic surfactant induces a response akin to heat-shock apoptosis in intestinal epithelial cells: implications for excipients safety

RJ Cavanagh, PA Smith, S Stolnik - Molecular Pharmaceutics, 2019 - ACS Publications
permeability as indicated by the release of LDH, internalization of FD4, and as a marker of
nuclear membrane permeability… components will likely promote immunogenic response in the …

A Narrative Review on Non-Invasive Drug Delivery of Teriparatide: A Ray of Hope

N Mittal, G Sharma, OP Katare… - Critical Reviews™ in …, 2023 - dl.begellhouse.com
… of glycoprotein present in mucus enhances the mucoadhesive properties of thiolated chitosan.…
CriticalSorbpromotes permeation of flux markers across isolated rat intestinal mucosae

Current and evolving approaches for improving the oral permeability of BCS Class III or analogous molecules

VS Dave, D Gupta, M Yu, P Nguyen… - Drug development …, 2017 - Taylor & Francis
… diffusion across cellular membranes and intestinal mucosa, … gastric mucus rheology and drug
flux across gastric mucus … polarity and promoting their transmembrane permeation. The ion-…

Nasal administration and plasma pharmacokinetics of parathyroid hormone peptide PTH 1-34 for the treatment of osteoporosis

RG Pearson, T Masud, E Blackshaw, A Naylor… - Pharmaceutics, 2019 - mdpi.com
… benefit from a permeation enhancer to promote absorption across the nasal mucosa into the
… liquid nasal spray formulation containing the permeation enhancer polyethylene glycol (15)-…

Development and in vivo evaluation of intranasal formulations of parathyroid hormone (1-34)

D Wang, Y Du, W Zhang, X Han, H Zhang, Z Wang… - Drug …, 2021 - Taylor & Francis
permeation enhancer to effectively and safely promote the absorption of PTH(1-34) across
the nasal mucosa. … macromolecular drugs crossing the nasal and intestinal mucosa in phase I …

In vitro and preclinical assessment of an intranasal spray formulation of parathyroid hormone PTH 1–34 for the treatment of osteoporosis

AJ Williams, F Jordan, G King, AL Lewis, L Illum… - International journal of …, 2018 - Elsevier
… , which has been shown to promote new bone formation. … drug across the mucosal
membrane and is non-toxic to the … This work exemplifies the potential of Solutol ® HS15 (CriticalSorb™…