Evaluation of sucrose laurate as an intestinal permeation enhancer for macromolecules: ex vivo and in vivo studies
F McCartney, M Rosa, DJ Brayden - Pharmaceutics, 2019 - mdpi.com
… , isolated rat intestinal tissue mucosae, and rat intestinal … increases in paracellular marker
fluxes and TEER reductions with 5 … [62] also compared C 10 with sucrose caprate in promoting …
fluxes and TEER reductions with 5 … [62] also compared C 10 with sucrose caprate in promoting …
Ex vivo intestinal sacs to assess mucosal permeability in models of gastrointestinal disease
SW Mateer, J Cardona, E Marks, BJ Goggin… - JoVE (Journal of …, 2016 - jove.com
… intestinal barrier function in animal models of gastrointestinal … the flux of a paracellular probe
across the mucosal surface at … apparent permeability (P app ) of a marker molecule across …
across the mucosal surface at … apparent permeability (P app ) of a marker molecule across …
[HTML][HTML] Sodium glycodeoxycholate and sodium deoxycholate as epithelial permeation enhancers: in vitro and ex vivo intestinal and buccal bioassays
DJ Brayden, V Stuettgen - European Journal of Pharmaceutical Sciences, 2021 - Elsevier
… the P app of the paracellular marker, FITC-dextran 4000 (FD4… H]-octreotide flux across isolated
rat colonic mucosae (iv) the … were efficacious at promoting transepithelial peptide flux, but …
rat colonic mucosae (iv) the … were efficacious at promoting transepithelial peptide flux, but …
Application of cell culture and tissue models for assessing drug transport
CU Nielsen, B Brodin - Analytical Techniques in the Pharmaceutical …, 2016 - Springer
… in terms such as flux, permeability or clearance. Considering the … and their use in investigating
intestinal permeability, drug-… to the presence of the mucus layer in the in vivo situation. …
intestinal permeability, drug-… to the presence of the mucus layer in the in vivo situation. …
Exposure to a nonionic surfactant induces a response akin to heat-shock apoptosis in intestinal epithelial cells: implications for excipients safety
… permeability as indicated by the release of LDH, internalization of FD4, and as a marker of
nuclear membrane permeability… components will likely promote immunogenic response in the …
nuclear membrane permeability… components will likely promote immunogenic response in the …
A Narrative Review on Non-Invasive Drug Delivery of Teriparatide: A Ray of Hope
N Mittal, G Sharma, OP Katare… - Critical Reviews™ in …, 2023 - dl.begellhouse.com
… of glycoprotein present in mucus enhances the mucoadhesive properties of thiolated chitosan.…
CriticalSorb™ promotes permeation of flux markers across isolated rat intestinal mucosae …
CriticalSorb™ promotes permeation of flux markers across isolated rat intestinal mucosae …
Current and evolving approaches for improving the oral permeability of BCS Class III or analogous molecules
… diffusion across cellular membranes and intestinal mucosa, … gastric mucus rheology and drug
flux across gastric mucus … polarity and promoting their transmembrane permeation. The ion-…
flux across gastric mucus … polarity and promoting their transmembrane permeation. The ion-…
Nasal administration and plasma pharmacokinetics of parathyroid hormone peptide PTH 1-34 for the treatment of osteoporosis
RG Pearson, T Masud, E Blackshaw, A Naylor… - Pharmaceutics, 2019 - mdpi.com
… benefit from a permeation enhancer to promote absorption across the nasal mucosa into the
… liquid nasal spray formulation containing the permeation enhancer polyethylene glycol (15)-…
… liquid nasal spray formulation containing the permeation enhancer polyethylene glycol (15)-…
Development and in vivo evaluation of intranasal formulations of parathyroid hormone (1-34)
D Wang, Y Du, W Zhang, X Han, H Zhang, Z Wang… - Drug …, 2021 - Taylor & Francis
… permeation enhancer to effectively and safely promote the absorption of PTH(1-34) across
the nasal mucosa. … macromolecular drugs crossing the nasal and intestinal mucosa in phase I …
the nasal mucosa. … macromolecular drugs crossing the nasal and intestinal mucosa in phase I …
In vitro and preclinical assessment of an intranasal spray formulation of parathyroid hormone PTH 1–34 for the treatment of osteoporosis
AJ Williams, F Jordan, G King, AL Lewis, L Illum… - International journal of …, 2018 - Elsevier
… , which has been shown to promote new bone formation. … drug across the mucosal
membrane and is non-toxic to the … This work exemplifies the potential of Solutol ® HS15 (CriticalSorb™…
membrane and is non-toxic to the … This work exemplifies the potential of Solutol ® HS15 (CriticalSorb™…