Crocin inhibits proliferation and induces apoptosis through suppressing MYCN expression in retinoblastoma

L Deng, J Li, S Lu, Y Su - Journal of Biochemical and Molecular …, 2019 - Wiley Online Library
Crocin is the main component of saffron, which exhibits … derived from dried stigmas of
Crocus sativus L., has long been … have found that crocin possessed significant antiproliferative

The impact of Crocus sativus stigma against methotrexate-induced liver toxicity in rats

R Hoshyar, A Sebzari, M Balforoush… - … of Complementary and …, 2020 - degruyter.com
… (Saffron) has long been well known for multiple medicinal … manifested through its
antiproliferative potential against A549 … effect of Crocus sativus stigma extract and crocin (trans-crocin

[HTML][HTML] 1H-NMR Metabolic Profiling and Antioxidant Activity of Saffron (Crocus sativus) Cultivated in Lebanon

H Samaha, N Chahine, AP Sobolev, L Menghini… - Molecules, 2021 - mdpi.com
… to obtain a major number of metabolites from the stigmas, … The Indian sample with the lowest
picrocrocin and crocin content has … and antiproliferative abilities in the A549 cancer cell line. …

Novel Extraction Techniques: An Effective Way to Retrieve the Bioactive Compounds from Saffron (Crocus Sativus)

A Rahaman, A Kumari, MA Farooq… - Food Reviews …, 2023 - Taylor & Francis
… [Citation6] Crocins (mainly α-crocin) have several … phytochemical field have tracked a variety
of components in saffron stigmas. … , saffron has great importance in the food sector due to its

[HTML][HTML] Toxicology effects of saffron and its constituents: a review

HB Bostan, S Mehri… - Iranian journal of basic …, 2017 - ncbi.nlm.nih.gov
… of saffron and its main constituents, crocin and safranal have … 50 values of saffron stigma
and petal extracts were 1.6 and 6 … of 200 mg/kg of saffron for 28 days significantly decreased …

An updated review on therapeutic effects of nanoparticle-based formulations of saffron components (safranal, crocin, and crocetin)

E Mirhadi, H Nassirli, B Malaekeh-Nikouei - Journal of Pharmaceutical …, 2020 - Springer
Saffron, the dried stigma of the flower of the Crocus sativus … 1a), is one significant bioactive
component in saffron that … In 2007, it was found that crocin has antiproliferative effects on …

[HTML][HTML] Advances on the anti-tumor mechanisms of the carotenoid Crocin

X Bao, J Hu, Y Zhao, R Jia, H Zhang, L Xia - PeerJ, 2023 - peerj.com
Saffron is located in the upper part of the crocus stigma of … As a carotenoid, crocin is an
active component in saffron. … In summary, crocin has a great potential in defeating tumors. …

Newly crocin-coated magnetite nanoparticles induce apoptosis and decrease VEGF expression in breast carcinoma cells

R Saravani, S Sargazi, R Saravani, M Rabbani… - Journal of drug delivery …, 2020 - Elsevier
Saffron, that is, the dried stigmas of Crocus sativus L., … ) is a potent antiproliferative metabolite
of saffron with important activity on … It has also been shown that crocin inhibits the growth of …

Crocus sativus L. (Iridaceae) (Syns.: C. officinalis (L.) Honck.; C. orsinii Parl.; C. pendulus Stokes; C. setifolius Stokes)

S Akbar, S Akbar - … Medicinal Plants: A Comprehensive Review of Their …, 2020 - Springer
… Chemical analysis of saffron stigmas has shown the presence of … Saffron extracts and crocins
ameliorate experimentally-… with aqueous extract significantly attenuated cerebral ischemia-…

… study on anti-invasion, antimigration, and antiadhesion effects of the bioactive carotenoids of saffron on 4T1 breast cancer cells through their effects on Wnt/β-catenin …

L Arzi, G Riazi, M Sadeghizadeh, R Hoshyar… - DNA and cell …, 2018 - liebertpub.com
Saffron is derived from the dried stigma of Crocus sativus L., … (antiproliferation and
proapoptotic) effects of crocin and crocetin on primary tumors have been proven, studies on their