Combination therapy with bispecific antibodies and PD-1 blockade enhances the antitumor potency of T cells

CH Chang, Y Wang, R Li, DL Rossi, D Liu, EA Rossi… - Cancer research, 2017 - AACR
cells, kill target cells with subnanomolar IC 50 when cocultured with T cells in vitro, and inhibit
growth of human tumor xenograftsT cells, which in comparison with treatments without the …

Bispecific antibodies enable synthetic agonistic receptor-transduced T cells for tumor immunotherapy

CH Karches, MR Benmebarek, ML Schmidbauer… - Clinical Cancer …, 2019 - AACR
… -LUC xenograft model, we could observe significant infiltration and persistence of E3 T cells
in the treated … expressing a SAR that can be targeted by the depleting monoclonal antibody

A novel carcinoembryonic antigen T-cell bispecific antibody (CEA TCB) for the treatment of solid tumors

M Bacac, T Fauti, J Sam, S Colombetti, T Weinzierl… - Clinical Cancer …, 2016 - AACR
… of CEA-expressing xenograft tumors with variable amounts of … activity of T cells by bispecific
antibodies against tumor cells, … in humans (as rat/mouse hybrid monoclonal antibody), …

A rationally designed fully human EGFRvIII: CD3-targeted bispecific antibody redirects human T cells to treat patient-derived intracerebral malignant glioma

PC Gedeon, TH Schaller, SK Chitneni, BD Choi… - Clinical Cancer …, 2018 - AACR
T cells can precisely eradicate tumors. Here we report the rational development of a fully
human bispecific antibody (… tumors, patient-derived xenografts were allowed to establish without …

A novel EGFRvIII T-cell bispecific antibody for the treatment of glioblastoma

…, X Guardia-Reyes, L Fahrni, T Pöschinger… - Molecular Cancer …, 2022 - AACR
… of human GBM samples were digested with the Human Tumor … Three days after treatment,
we observed that CD3 T cells … of CD3 T cells expressing luciferase in U87MG xenografts on …

Harnessing T cells to fight cancer with BiTE® antibody constructs – past developments and future directions

M Klinger, J Benjamin, R Kischel… - Immunological …, 2016 - Wiley Online Library
… concept of bispecific antibodies for redirecting T cells being 30 … Targeting CD20 with the
chimeric monoclonal antibody … in the human prostate cancer xenograft model, the tumor uptake …

Combination of T-cell bispecific antibodies with PD-L1 checkpoint inhibition elicits superior anti-tumor activity

J Sam, S Colombetti, T Fauti, A Roller, M Biehl… - Frontiers in …, 2020 - frontiersin.org
treatment increases the frequency of total intra-tumor T-cells, and … The anti-PD-L1 monoclonal
antibody used in the … ) bearing a human gastric adenocarcinoma xenograft tumor (MKN-…

[HTML][HTML] Potent ex vivo armed T cells using recombinant bispecific antibodies for adoptive immunotherapy with reduced cytokine release

JA Park, BH Santich, H Xu, LG Lum… - … of cancer, 2021 - ncbi.nlm.nih.gov
… multiple cancer cell lines and patient-derived xenograft mouse … (γδ) T cells were investigated
as unrelated alternative effector T … of T cells in the blood and tumors after γδ-EAT treatment

A novel T cell-engaging bispecific antibody for treating mesothelin-positive solid tumors

A Yoon, S Lee, S Lee, S Lim, YY Park, E Song, DS Kim… - Biomolecules, 2020 - mdpi.com
… and produced regression of xenograft tumors with CD8+ T-cell … of circulating T cells. Thus,
MG1122-B may be useful for … monoclonal antibody, we used the mouse anti-human CD3ε …

[HTML][HTML] Targeting tumor vasculature to improve antitumor activity of T cells armed ex vivo with T cell engaging bispecific antibody

JA Park, M Espinosa-Cotton, H Guo… - … of Cancer, 2023 - ncbi.nlm.nih.gov
cancer cell line-derived xenografts (CDXs) or patient-derived … hCD45(+) T cells than tumors
treated with unarmed T cells as … is known to increase levels of plasma hVEGF in human tumor