… The whole genome sequencing studies showed very less difference between the current …
The Δcaf mutant was observed as virulent as WT CO92 in the pneumonic plague (29). In …

… 66c (encoding a putative helicase) was identified as required for bacterial intracellular survival
during the early stages of bubonic plague [61]. Besides known virulence genes, genome-…

… new insights into the nature and etiology of infectious diseases of historical importance, such
as plague, … Elucidating the genomic basis of virulence in historical diseases can provide …

… ), was that of the notorious bacterial pathogen Yersinia pestis, the causative agent of plague…
virulence genes over their evolutionary time frames. Here, we show an example of virulence …

… as one of the most virulent human pathogens. In late 2017, a large plague outbreak raged
in … summarized different kinds of plague vaccine developments, including live recombinant, …

… plague pathogen is benefitted by having additional virulence factors extending beyond its
T3SS injectosome. Although the 70-kb virulence … rooted in host genetics rather than reversion …

… The key issues need to be solved in future … genome sequencing from infected human skeletal
remains dating from the Stone Age, already had most if not all the plague-related virulence …

… of the plague bacterium from the different eras, the detected loss of a genomic region that
includes virulence-… to gain a more comprehensive understanding of all these pending issues. …

… Here we present reconstructed Y. pestis genomes from plague victims of the Black Death
and two subsequent … ) to become one of the most virulent pathogens known to humans. Its …

… three major plague pandemics (Justinianic, Medieval and Modern). Previous studies on …
pestis strains (including the two Danish genomes reconstructed in this study: Sejet Ødekirkegård …