… fimA and fimH to examine the participation of type 1 fimbriae in … We focused on TLR4 as a
receptor for FimH and examined … coli FimH is reported to be a protein ligand for TLR4 (25, 26). …

… In this study, FimH is defined as a broad, mostly inhibitory … as neurokinin ligand-receptor
networks. C. ABU strains like E. … involved in TLR4 signaling, upstream of IRF7 and type 1 IFN …

… FimH is the adhesion portion of type 1 fimbriae in … Since FimH stimulates TLR4, we hypothesize
that it may function … LPS is the most well-known TLR4 ligand that induces the maturation …

… FimH, the adhesion portion of type I fimbriae, is a highly conserved protein located on the
surface of Escherichia coli (E. coli) (19). As a toll-like receptor 4 (TLR4) ligand, FimH can …

… Here, we focus on type 1 fimbriae and its adhesin FimH, one of the most abundant … -specific
receptor-ligand interactions. It is widely accepted that type 1 fimbrial FimH adhesins bind to …

… Thus, a novel multi-epitope protein composed of FimH, FyuA, … Molecular docking indicated
that thirty six ligand residues of … of FimH in the protein with Toll-like receptor 4 (TLR-4) on Ht29 …

… like fibrinogen or cellular ligands like ICAM- 1. This integrin gain … TLR4 which was previously
suggested as a receptor for the … of FimH to CD14 is causative for the increase in adhesion of …

… Type 1 pili-mediated adhesion to host cells is a crucial step … the effect of preventing FimH
sensing by TLR4 with TAK-018 … (CRD) of FimH, by mimicking its natural ligand, appears of great …

… , we observe that FimH adhesin of type 1 pili facilitate ETEC adhesion, antibody mediated or
… Cutting edge: FimH adhesin of type 1 fimbriae is a novel TLR4 ligand. J Immunol. 2008;181(…

… fimbriae (AAF). EAEC prototypical strain 042 harbors the AAF/II fimbriae variant, which mediates
adhesion … We hypothesized that AAF/II could be a novel TLR4 agonist that induces IL-8 …