… that dietary polyphenols participate in the downregulation of cyclooxygenase-2 (COX-2), an
… inhibit the effects of COX-2 in colon cancer, by examining the available evidence regarding …

… characterized is cyclooxygenase-2 (COX-2… cyclooxygenase-2 is accompanied by increased
expression of nuclear factor-kappa B and I kappa B kinase-alpha in human colorectal cancer …

… % of all annually diagnosed cancer and 8.7% of cancer-related deaths [Citation2]… Colorectal
cancer is also known as colon cancer or rectal cancer, a major reason for the development …

… , KR; Smith, WL Asymmetric acetylation of the cyclooxygenase-2 homodimer by aspirin and
its effects on the oxygenation of arachidonic, eicosapentaenoic, and docosahexaenoic acids. …

… chronic inflammatory diseases and various cancers. COX-2 promotes colorectal cancer
through various signaling pathways. COX-2 plays its role in colorectal cancer by induction of Bcl-…

… Colorectal cancer … the development of invasive cancer [4]. Formation of benign precancerous
polyps that is characterized by the aggregation of abnormally dividing cells in the intestinal …

… Chronic inflammation is one of the known risk factors for colorectal cancer. … for developing
colorectal adenomas and colorectal cancer and suppresses colorectal cancer development (1)…

… (EP4) receptor and its pathways have also … colorectal cancer along with increases in the
levels of prostaglandin E 2 (PGE 2 ) and cyclooxygenase-2 (COX-2), the hallmarks of colorectal …

… Colorectal cancer (CRC) is the third most common cancer and the third leading cause of
cancer-related mortality in the USA ( Siegel et al., 2016 ). A number of risk factors for sporadic …

… cancers, cyclooxygenase-2 (COX-2) has been found to be intimately associated with several
types of cancers [3… metastases of colorectal carcinoma [13], gastrointestinal cancers, thyroid …