… Epithelial cell stress and apoptosis in response to AD … and its metabolite, N-desethylamiodarone
(DEA) in high lipid … AD-induced direct cytotoxicity involves accumulation of …

… Amiodarone and desethylamiodarone have a very long … in thyroid, liver, adipose tissue and
lungs (Gupta et al., 2003; Eskes … cytotoxicity induced by amiodarone in the mouse fibroblastic …

… levels of amiodarone and its metabolite, desethylamiodarone, … the lung parenchyma as a
result of direct cytotoxicity to … that amiodarone induces apoptosis of alveolar epithelial cells in …

… and vacuolization of the bronchial epithelial cell. This is … in normal peripheral blood
mononuclear cells via modulation of the NF-… Vitexin on activated human peripheral blood …

… IGF-1 failed to suppress amiodarone-induced cytotoxicity and the … The amiodarone metabolite,
N-desethylamiodarone (DEA), … in amiodarone-induced toxicity in human peripheral lung …

… Cell viability and cytotoxicity assays in primary human cardiac … In conclusion, our
findings from in vitro experiments on human cardiac cell lines reveal that amiodarone, but not …

… amiodarone-induced apoptosis of alveolar epithelial cell, that … of pulmonary involvement
following amiodarone assumption: … possible mechanisms: a direct cytotoxic effect or an immuno-…

… In this chapter, the discovery of the fact that amiodarone could inhibit this major metabolic …
that amiodarone can alter mitochondrial functions in other tissues such as the lung and …

… is destructive thyroiditis caused by amiodarone, desethylamiodarone as its main metabolite,
… cell lysis11,49. These results support the fact that amiodarone achieves most of its cytotoxic …

… desethylamiodarone activates both necrotic and apoptotic pathways in the culture of human
peripheral lung epithelial cells … and the release of cytotoxic and inflammatory mediators such …