In Vitro–In Vivo Extrapolation by Physiologically Based Kinetic Modeling: Experience With Three Case Studies and Lessons Learned
EA Algharably, E Di Consiglio, E Testai… - Frontiers in …, 2022 - frontiersin.org
… , amiodarone, and chlorpyrifos) with different kinetic and dynamic behaviors. In vivo human
… concentration at which 10% cytotoxicity was observed and hence equivalent to an in vivo …
… concentration at which 10% cytotoxicity was observed and hence equivalent to an in vivo …
The rationale for “Laser-induced thermal therapy (LITT) and intratumoral cisplatin” Approach for cancer treatment
RV de Brito, MW Mancini, MN Palumbo… - International Journal of …, 2022 - mdpi.com
… In studying the relationship of light with cytotoxic agents (such as cisplatin), we can assess
the beneficial association in combating tumor cells by focusing on oxidative stress. There are …
the beneficial association in combating tumor cells by focusing on oxidative stress. There are …
Hypersensitivity Pneumonitis
PS Shankar - Textbook of Pulmonary and Critical Care Medicine …, 2017 - books.google.com
… Some of this cytotoxicity … Amiodarone is an unusual drug as it is an iodinated benzofuran
derivative and its primary metabolite is created by the liver conversion of desethylamiodarone …
derivative and its primary metabolite is created by the liver conversion of desethylamiodarone …
Drug-induced thyroid dysfunction
V Bernet, RC Smallridge - … Management of Thyroid Disease, Third …, 2018 - taylorfrancis.com
… T-cell checkpoint blockade in patients with nonsmall cell lung … the anti-cytotoxic T
lymphocyte-associated antigen 4 mono- … Effects of amiodarone and desethylamiodarone on …
lymphocyte-associated antigen 4 mono- … Effects of amiodarone and desethylamiodarone on …
[图书][B] Hale's Medications & Mothers' Milk 2025-2026: A Manual of Lactational Pharmacology
TW Hale, K Krutsch - 2024 - books.google.com
… entry of that medication into human milk. … cell walls of the mammary epithelium (see ethanol).
Drugs with higher molecular weights must traverse the membrane by dissolving in the cells' …
Drugs with higher molecular weights must traverse the membrane by dissolving in the cells' …
Lipoproteins and the tumor microenvironment
AS Dossou, N Sabnis, B Nagarajan, E Mathew… - … Matrix Components–Part …, 2020 - Springer
… proliferation via mesenchymal-epithelial cell interactions. … In addition, the infiltration of
CD8 + , cytotoxic T cells into the TME is inhibited by TAMs in human lung squamous cell …
CD8 + , cytotoxic T cells into the TME is inhibited by TAMs in human lung squamous cell …
The Role of Macrophages in the Sequestration of Drug and Formation of Insoluble Drug Aggregates
P Rzeczycki - 2018 - deepblue.lib.umich.edu
… to be detrimental to the health of cells [37], it is believed that … put in place to curtail the
cytotoxic effects of the drug [5]. … a variety of epithelial cells, from the intestines to the lung [55]…
cytotoxic effects of the drug [5]. … a variety of epithelial cells, from the intestines to the lung [55]…
[HTML][HTML] Recent advancements in single-cell metabolic analysis for pharmacological research
Y Hou, H Yao, JM Lin - Journal of Pharmaceutical Analysis, 2023 - Elsevier
… [29] reported a single-cell cytotoxicity evaluation and selective release method. Natural …
amiodarone (AMIO) and its major metabolite, N-desethylamiodarone (NDEA), in individual cells. …
amiodarone (AMIO) and its major metabolite, N-desethylamiodarone (NDEA), in individual cells. …
Impacts of the Immune System on Small Molecule Pharmacokinetics
A Willmer - 2023 - deepblue.lib.umich.edu
… Amiodarone is another medication that causes structural phase transitions in … Amiodarone
is limited to a maximum total dose in patients due to cumulative side effects. As a result, lung …
is limited to a maximum total dose in patients due to cumulative side effects. As a result, lung …
Endocrine System
SA Alenezi, AH Elgazzar - The Pathophysiologic Basis of Nuclear …, 2022 - Springer
… thyroid hormone, surrounded by epithelial cells. The function of the … , which appears to be
related to a cytotoxic effect [18, 19]. … Since amiodarone and its metabolite desethylamiodarone …
related to a cytotoxic effect [18, 19]. … Since amiodarone and its metabolite desethylamiodarone …