… mechanism of amiodarone-induced toxicity in liver and other tissues such as lung and thyroid
(… Indeed, at low concentrations (<100 μM), amiodarone is able to uncouple OXPHOS and …

… Amiodarone is metabolized through hepatic cytochromes CYP3A4 and CYP2C8 into an active
metabolite, desethylamiodarone (DEA). … Amiodarone and DEA inhibit several cytochrome …

… a former mechanism for AMD-induced cytotoxicity. AMD has a tendency for … amiodarone on
phospholipid content and composition in heart, lung, kidney and skeletal muscle: relationship …

… Among a large variety of drugs that have been reported to … ), we draw special attention to
amiodarone, dichloroacetate, and … (desethylamiodarone and bis-desethylamiodarone) are likely …

… Activated NK cells can release perforin and granzyme B, cytotoxic proteins that form pores in
the … Amiodarone is metabolized predominantly to mono–N–desethylamiodarone (DEA), but …

… It predominantly penetrates the epidermal layer and is significantly more cytotoxic, with a …
Phototoxicity is driven by amiodarone and its metabolite, desethylamiodarone, producing …

… cultured human skin fibroblasts chronically exposed to amiodarone and desethylamiodarone
(… fibroblast cells significantly protected against ciprofloxacin (CPFX)-induced cytotoxicity. It …

… patients with chronic obstructive pulmonary diseases including … In the thyroid gland of humans
amiodarone concentration is … Cytotoxic effects of amiodarone and desethylamiodarone on …

… and splenocytes ex vivo, but induced cytotoxicity of both bone marrow cells and splenocytes
… lung tissues to mono-N-desethylamiodarone (MDEA), the main metabolite of amiodarone. …

… The method compares the cytotoxicity of a chemical on … Amiodarone/desethylamiodarone
in the triplet excited state … drugs approved for the treatment of idiopathic pulmonary fibrosis, …