… to result from direct cytotoxic effects of amiodarone on thyrocytes. … of peripheral and central
T 4 -to-T 3 conversion by amiodarone and its major active metabolite, desethylamiodarone, …

… head, neck, breast, and lung8. MTX may cause hepatotoxicity … However, the cytotoxic
and immunologic effects of phenytoin … both amiodarone and its metabolite N-desethylamiodarone …

… of lysosomal lipases by amiodarone inducing hepatic phospholipidosis … toxic effects in humans
such as hepatotoxicity, lung toxicity, … The acetyl isoniazid is then hydrolyzed into cytotoxic …

… 4-ipomeanol or promote cytotoxicity in HepG2 cells and primary human T-cells that …
Antonini, JM and MJ Reasor, Accumulation of amiodarone and desethylamiodarone by rat …

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… We show that amiodarone is also a potent inhibitor of several … its active metabolite
mono-N-desethylamiodarone (MDEA) has a … oxidative products may have cytotoxic effects in the …

… three examples (ibuprofen, amiodarone, and chlorpyrifos) … cytotoxicity was observed and
hence equivalent to an in vivo … the circulation system was closed via the lung and the heart. The …

… induced heart valve disease and pulmonary hypertension. Indeed, it … The MTT cytotoxicity
assay is a colorimetric method for … Amiodarone is an example of a drug that affects multiple …

… In studying the relationship of light with cytotoxic agents (such as cisplatin), we can assess
the beneficial association in combating tumor cells by focusing on oxidative stress. There are …

In the currently overwhelming era of polypharmacy, the balance of the dynamic and delicate
endocrine system can easily be disturbed by interfering pharmaceutical agents like …