… Plasmodium falciparum dihydropteroate synthase (Pfdhps) and … Clinical trials to investigate
the efficacy of IPT-SP are much … Pyrimethamine binds far more strongly to the parasite DHFR …

… with in vitro activity of pyrimethamine and cycloguanil, but not with sulfadoxine-pyrimethamine
treatment efficacy,” … falciparum: genotyping of dihydrofolate reductase and dihydropteroate …

… mutants that were associated with pyrimethamine resistance … three localities suggests the
efficiency of SP as IPTp. Citation62 This … treatment with sulfadoxine/pyrimethamine in Gabon. J …

… with resistance to pyrimethamine and pfdhps 436A/F/H and … /S, associated with resistance
to cycloguanil [18] and mutation … with genotypes known to compromise SP efficacy in Gabi are…

… falciparum dihydrofolate reductase [Pfdhfr], respectively [5]. … resistance are widespread, SP
plus AQ remain efficacious in … preventive treatment [IPTi] with SP alone in infants in Gabon, …

… their efficacy has to be regularly under surveillance. Indeed, sulfamides association such as
sulfadoxinepyrimethamine (… -pyrimethamine treatment failures in vivo in Gabonese children,” …

… (AL), and sulfadoxine–pyrimethamine (SP) has been the … -level resistance toward
pyrimethamine. Additive mutations at … T, which is associated with cycloguanil resistance, in the …

… Resistance to Sulfadoxine-Pyrimethamine is mediated by … of efficacy of core inhibitors
of this class like pyrimethamine … (PG; metabolized in vivo to the active form cycloguanil [CG]) …

… mutations eroding the efficacy of sulfadoxine-pyrimethamine (SP)… We report for the first time
mutation I164L-dhfr and I431V-dhps in … For genotypes of Pfdhfr, five kinds of genotypes were …

… (Pfdhps) genes confer resistance to pyrimethamine and … of SP efficacy studies for
intermittent preventive treatment in … Currently, sulfadoxine-pyrimethamine (SP) is the only anti-…