… of type I interferons in the CNS, focusing on possible signaling … of IFN-α activates the
intracellular mediator mechanistic target … , which corresponds nicely to the immune dysfunction …

… dysfunction and DNA oxidation, followed by activation of the … various SASP mediators, resulting
in paracrine signalling and … leading to DNA damage in the human central nervous system …

… by which DNA damage may mediate neuronal dysfunction. … that their locations are likely
major mediators of their toxicity. As … that DNA damage can also evoke type-I interferon signaling …

… DNA damage and type I interferons (IFNs) contribute to … TBI increased expression of
proinflammatory mediators in the … to implicate IFN-β in the development of neurological …

… in the maintenance of immune responses in the brain. The … stimulate TBK1 to mediate an
interferon response. Whereas STING … DNA, leading to a greater susceptibility to DNA damage. …

… Released mtDNA can mediate inflammatory responses … in the nuclear DNA damage response
(as reviewed in [12]). When … Here, we focus on major depressive disorder as we believe it …

… We demonstrate that neuronal IFNβ-IFNAR1 signaling … of TLR9 in neuronal dysfunction
caused by damaged KOmtDNA, … key mediator of TLR4 activation in response to damaged mtDNA …

… more common interferon dysfunction diseases that they have parallels with, has allowed for
great advances in the development of interferon … of an anti-interferon signalling therapy, a full …

… causally related to neuronal loss and synaptic damage is still … be an inflammatory amplification
signal that promotes activation … mediator from immune cells to neurons exacerbating their …

… dysfunction contributing to the cellular damage. Stimulator of … identified the type-I IFN pathway
as a key mediator of … for STING in mediating type-I IFN signalling and proposes STING as a …