… Given the importance of Cdk1 in resection and the DNA damage checkpoint response, we
… as the ideal template for homologous recombination. Our new finding demonstrates that …

… DNA DSB repair by HR requires many enzymes and protein complexes that effectively …
step of the repair process. In this review, we focus on the process of DNA end resection and its …

… CDK1 in yeast is essential for DSB end resection and consequently for checkpoint activation
and repair … playing a critical role in HR by stimulating DNA end resection [93]. BRCA1–CtIP …

… checkpoint responses, but CDK activity is required for efficient HR. Here, we show that ATR
promotes HR after CDK-driven DNA end resection… HR in G1, when CDK1/2 activities are low. …

… ) that channels DSB repair into homologous recombination. … Much of our knowledge about
the DNA end resection mechanism … Furthermore, substitution of three Cdk1 consensus sites of …

… DNA damage repair by homologous recombination … occurs, the end resection process resects
the broken ends of the DNA; (ii) … DNA ends to the opposite end of the damaged DNA. After …

… signaling via the activation of the ATM-dependent DNA damage checkpoint [8]. Mutations in
… DNA end resection [17]. Cdc28/Clb1 (Cdk1/cyclin B) phosphorylates Sae2 (the CtIP homolog…

… WEE1 which phosphorylates and inactivates both CDK1 and … is required for efficient DNA
end resection and activation of ATR … in cell cycle checkpoints’. However, a direct role of ATM in …

… and cell cycle regulators including the cell cycle checkpoint kinase 1 and 2 (CHK1 and CHK2…
role of CDC25 in CDK1 activation, the WEE1 kinase phosphorylates and inactivates CDK1; …

… the activity of homologous recombination repair (HRR) and enhanced the antitumor activity
of a poly(ADP-ribose) polymerase (PARP) inhibitor and other DNA-damaging agents in …