… DNA ligase III activation and the alignment of DNA ends … in tumors deficient in homologous
recombination repair (HRR) … B–CDK1. ATM itself appears to contribute a minor role to the …

… -prone non-homologous end joining (NHEJ) pathways … DNA ends permitting the following:
First, telomere capping which is essential for the inhibition of the telomere 5′-end resection,…

… mainly by high-fidelity homologous recombination (HR) or … at DSB sites and facilitating
DNA end resection, in which its … The inactivation of the CDC family causes CDK2 and CDK1 …

… Taken together, inhibition of CDK1 causes activation of the DNA damage … a G1 DNA damage
checkpoint, but it also participates directly in the DDR pathway downstream of activation of …

… Both DNA end resection and DNA damage checkpoint have … mechanisms to repair DSBs:
Non Homologous End Joining (… most important residue for Cdk1 phosphorylation is Serine 267…

… with defects in homologous recombination DNA repair (HRR) (… , DNA-PKcs, modest end
resection, limited by 53BP1, and … M cyclin dependent kinases CDK2 and CDK1 causing S-phase …

… Despite the weaker impact of homologous recombination (HR) deficiency on TMB relative
to MMRd, catastrophic DNA damage driven by DDRi can be favorable to enhance ICB therapy …

… to eliminate DSBs from the genome: non-homologous end joining (NHEJ) and homologous
… As cells enter S/G2 phase, end resection is activated via CDK1/2 mediated CtIP …

… the non-homologous end-joining (NHEJ) DSB repair pathway (… as a DNA sensor protein
has the ability to bind DNA ends, … dephosphorylation of CDK1–cyclin B, which is required for …

… CDK1, and shRNA-mediated CHK1 knockdown suppressed the induction of pS216 CDC25c
and pY15 CDK1 by … forces cells to enter mitosis with unrepaired DNA damage. HR and non-…