… non-homologous end-joining (cNHEJ) and homologous … ATRi and other DNA damage
checkpoint inhibitors in patients … of DNA end resection at DSBs, functioning with BRCA1 in both …

… deficiency impairs DNA DSB repair by homologous recombination (… DNA end resection
activate DNA damage checkpoints that slow down cell cycle progression and allow time for repair…

… may also participate in non-homologous end joining (NHEJ), … derived from DNA end
resection, protecting DNA tail from … Additionally, CDK1 and CDK2 appear to be associated with …

… to repair DSBs: classical non-homologous end joining (c-NHEJ) … not only inhibits NHEJ,
which prefers blunt DNA ends, but also … Although DNA-end resection plays a vital role in repair …

… signal at the DNA damage checkpoint (Rad9 in yeast, 53BP1 in humans) and the replication
… The replication fork accumulates free DNA ends and ssDNA fragments, while continuous …

… ATM is demonstrated to favor homologous recombination (HR… steps of HR after DSB end
resection and RAD51 loading [59]… molecule inhibitor of Cdk2, Cdk5, Cdk1 and Cdk9, is the first …

… DNA damage checkpoint defects, impaired DNA repair and … DNA repair initiation, specifically
non-homologous end joining. An … DNA end resection and alteration in translocatome [184] …

… kinase (WEE1), which then phosphorylates CDK1, reducing … in promoting repair through
homologous recombination (HR) … regarding the connection of open DNA ends, as the MRN …

… role for CDKs in the cellular response to DNA damage (23). CDKs play crucial roles in
both the activation of DNA damage checkpoint signaling and HR-dependent DNA repair. (31–34). …

… end-‐joining or … Non-‐homologous end joining and homologous recombination are the two
main … helicases in a mechanism called DNA end resection that creates single-stranded DNA …