The diverse roles of DNA methylation in mammalian development and disease

MVC Greenberg, D Bourc'his - Nature reviews Molecular cell biology, 2019 - nature.com
functions of DNA methylation and its establishment, maintenance and erasure during mammalian
development. … into the patterning of DNA methylation during development. Finally, we …

Role of mammalian DNA methyltransferases in development

Z Chen, Y Zhang - Annual review of biochemistry, 2020 - annualreviews.org
DNA methylation at the 5-position of cytosine (5mC) plays vital roles in mammalian development.
DNA methylation is catalyzed by DNA methyltransferases (DNMTs), and the two DNMT …

DNA methylation reprogramming during mammalian development

Y Zeng, T Chen - Genes, 2019 - mdpi.com
… , are usually devoid of methylation [2]. DNA methylation is essential for mammalian development
and is involved in … Aberrant DNA methylation patterns and mutations of genes encoding …

Dynamics and context-dependent roles of DNA methylation

C Ambrosi, M Manzo, T Baubec - Journal of molecular biology, 2017 - Elsevier
DNA methylation is one of the most … important roles during mammalian development. Its
perturbation is often associated with human diseases. In mammalian genomes, DNA methylation

DNA methylation and the preservation of cell identity

O Bogdanović, R Lister - Current opinion in genetics & development, 2017 - Elsevier
… Nevertheless, targeted deposition and removal of DNA methylation by DNMTs and … roles
of DNA methylation in the establishment and maintenance of cell identity during development, …

DNA methylation and DNA methyltransferases

JR Edwards, O Yarychkivska, M Boulard… - Epigenetics & …, 2017 - Springer
DNA methylation in mammals (which has been the subject of many reviews), we present a
new analysis of the distribution of methylated … genomes during mammalian development. The …

DNA methylation homeostasis in human and mouse development

M Iurlaro, F von Meyenn, W Reik - … opinion in genetics & development, 2017 - Elsevier
… Over the past few years, our understanding of the regulation of DNA methylation during
mammalian development has progressed tremendously however a number of central questions …

DNA methylation: a historical perspective

AL Mattei, N Bailly, A Meissner - Trends in Genetics, 2022 - cell.com
role and interpretation of DNA methylation patterns remain under investigation. Here, we
review the field of DNA methylation … an emphasis on findings in mammalian systems, and point …

Establishment and functions of DNA methylation in the germline

KR Stewart, L Veselovska, G Kelsey - Epigenomics, 2016 - Future Medicine
… These studies will continue to expand our understanding of mammalian development,
and will also shed light on how well murine gametogenesis and embryogenesis model these …

Recent progress towards understanding the role of DNA methylation in human placental development

T Bianco-Miotto, BT Mayne, S Buckberry… - …, 2016 - rep.bioscientifica.com
role DNA methylation plays in regulating placental gene expression across gestation are
poorly understood. We review genome-wide DNA methylation … very different DNA methylation