DNA methylation is an independent prognostic marker of survival in adrenocortical cancer

A Jouinot, G Assie, R Libe, M Fassnacht… - The Journal of …, 2017 - academic.oup.com
… , somatic mutations, chromosomal alterations, and DNA methylation could identify subgroups
of ACC with markedly different outcomes (7–9). DNA methylation might be involved in the …

DNA methylation profiling reveals prognostically significant groups in pediatric adrenocortical tumors: a report from the International Pediatric Adrenocortical Tumor …

MR Clay, EM Pinto, C Cline, QT Tran, T Lin… - JCO Precision …, 2019 - ascopubs.org
… Our results indicate DNA methylation analysis can enhance current diagnostic algorithms.
A combination of methylation and histologic classification produced the strongest prediction …

DNA methylation is a comprehensive marker for pediatric adrenocortical tumors

AC Bueno, RMP da Silva, MF Stecchini… - Endocrine-Related …, 2022 - erc.bioscientifica.com
… In the present study, we aimed to analyze the DNA methylation profile of pACT samples
from a Brazilian cohort enriched with the Gp53-p.R337H mutation. We established two …

[HTML][HTML] Pathway implications of aberrant global methylation in adrenocortical cancer

CR Legendre, MJ Demeure, TG Whitsett, GC Gooden… - PLoS …, 2016 - journals.plos.org
… assess DNA methylationDNA methylation changes in ACC in the past, our study is distinct
in the manner in which we describe DNA methylation/gene expression associations to identify

DNA methylation of steroidogenic enzymes in benign adrenocortical tumors: new insights in aldosterone-producing adenomas

G Di Dalmazi, L Morandi, B Rubin… - The Journal of …, 2020 - academic.oup.com
DNA methylation of CYP11B1 seems not to be relevant in determining cortisol overproduction
in adrenal … in our study showed that adrenal incidentalomas and ACS were spread among …

[HTML][HTML] Global DNA methylation analysis identifies two discrete clusters of pheochromocytoma with distinct genomic and genetic alterations

S Backman, R Maharjan, A Falk-Delgado, J Crona… - Scientific reports, 2017 - nature.com
… This study included 39 tumours and 4 normal adrenal medullas. This is the only independent
… defined by DNA methylation were validated while proposed markers of malignancy could …

[HTML][HTML] Past, present and future of epigenetics in adrenocortical carcinoma

M Ettaieb, T Kerkhofs, M van Engeland, H Haak - Cancers, 2020 - mdpi.com
DNA methylation profiling has been suggested a reliable technique to distinguish between
benign and malignant adrenocortical … between benign and malignant adrenal tumors is of the …

[HTML][HTML] Intratumor heterogeneity of prognostic DNA-based molecular markers in adrenocortical carcinoma

A Jouinot, J Lippert, M Fassnacht… - Endocrine …, 2020 - ec.bioscientifica.com
markers measurable at the DNA level – somatic mutations, chromosome alteration profile
and targeted DNA methylation profile – by performing multiple measures for different tumor …

[HTML][HTML] HPA axis dysregulation is associated with differential methylation of CpG-sites in related genes

A Chatzittofis, ADE Boström, DM Ciuculete… - Scientific Reports, 2021 - nature.com
DNA methylation shifts in Hypothalamic–pituitary–adrenal (… dysregulation, shifts in DNA
methylation of HPA axis related … Our findings revealed that DNA methylation shifts are involved …

[HTML][HTML] Alterations of DNA methylation were associated with the rapid growth of cortisol-producing adrenocortical adenoma during pregnancy

C Wang, Y Sun, X Yin, R Feng, R Feng, M Xu… - Clinical …, 2021 - Springer
… and examined the genome-wide DNA methylation profiles of non-pregnant and pregnant
patients with CPA. We aimed to identify the differences in DNA methylation signatures of non-…