[HTML][HTML] Advances in epigenetic therapeutics with focus on solid tumors
N Jin, TL George, GA Otterson, C Verschraegen… - … epigenetics, 2021 - Springer
… effectiveness of both broad and targeted epigenetic therapies. Broad-spectrum reprogrammers
include the inhibitors of DNA methyltransferase (DNMT), histone deacetylase (HDAC) …
include the inhibitors of DNA methyltransferase (DNMT), histone deacetylase (HDAC) …
[HTML][HTML] Role of epigenetic modifications in inhibitory immune checkpoints in cancer development and progression
… ICs and their ligands, within … epigenetic alterations, including DNA methylation, histone
modifications and microRNAs (3, 28, 29). Epigenetic modifiers, including DNA methyltransferase …
modifications and microRNAs (3, 28, 29). Epigenetic modifiers, including DNA methyltransferase …
Role of epigenetic drugs in sensitizing cancers to anticancer therapies: emerging trends and clinical advancements
… involved in regulating epigenetic changes to … inhibitors and DNA methyltransferase inhibitors,
among others. These drugs have shown potential as standalone treatments for cancer and …
among others. These drugs have shown potential as standalone treatments for cancer and …
[HTML][HTML] Epigenetic Regulation in Breast Cancer: Insights on Epidrugs
A Kim, K Mo, H Kwon, S Choe, M Park, W Kwak… - Epigenomes, 2023 - mdpi.com
… cancer. Wnt antagonist genes, such as SERP and DKK, are regulated by epigenetic silencing
via DNA methylation in breast cancer. β-… epigenetic therapies for the treatment of cancer. …
via DNA methylation in breast cancer. β-… epigenetic therapies for the treatment of cancer. …
Epigenetic control of gene expression: Potential implications for cancer treatment
… Examples of epigenetic control are DNA methylation, histone … In summary, epigenetic
therapy has reached so far … , and several epigenetic drugs are now clinically approved for their …
therapy has reached so far … , and several epigenetic drugs are now clinically approved for their …
Epigenetic approach for angiostatic therapy: promising combinations for cancer treatment
RH Berndsen, UK Abdul, A Weiss, M Zoetemelk… - Angiogenesis, 2017 - Springer
… of histone deacetylase and DNA methyltransferase inhibitors and their combinations with …
in treatment of solid tumors. The role that these inhibitors play in the inhibition of tumor …
in treatment of solid tumors. The role that these inhibitors play in the inhibition of tumor …
The roles of DNA, RNA and histone methylation in ageing and cancer
… of epigenetic therapies aimed at resetting the methylation … the cellular functions of chromatin
methylation and focus on … genes are silenced by DNA methylation in cancer 26 . Furthermore…
methylation and focus on … genes are silenced by DNA methylation in cancer 26 . Furthermore…
Emerging epigenetic-modulating therapies in lymphoma
D Sermer, L Pasqualucci, HG Wendel… - Nature reviews Clinical …, 2019 - nature.com
… epigenetic therapies for the treatment of lymphomas, including inhibitors of histone deacetylases
(HDACs), DNA … Additionally, patterns of aberrant DNA methylation have been observed …
(HDACs), DNA … Additionally, patterns of aberrant DNA methylation have been observed …
Improving cancer immunotherapy with DNA methyltransferase inhibitors
MH Saleh, L Wang, MS Goldberg - Cancer Immunology, Immunotherapy, 2016 - Springer
… significantly enhanced when they were treated with the combination of epigenetic modification
and checkpoint blockade relative to epigenetic therapy alone [53]. The addition of anti-PD-…
and checkpoint blockade relative to epigenetic therapy alone [53]. The addition of anti-PD-…
[HTML][HTML] Nucleosidic DNA demethylating epigenetic drugs–a comprehensive review from discovery to clinic
… and drawbacks of nucleosidic DNA methylation inhibitors, which will assist … therapeutic
efficacy of these drugs and circumvent the challenges in the path of successful epigenetic therapy…
efficacy of these drugs and circumvent the challenges in the path of successful epigenetic therapy…