… cancer development and, more specifically, colorectal cancer, along with the potential uses
of epigenetic therapy… of tumor suppressor along with DNA methylation cause cancer initiation …

… phenotype, epigenetic therapies gain more and more clinical relevance. Pioneering these
… of DNA methyltransferase (DNMT) inhibitors (DNMTi), which incite global cellular DNA …

… of epigenetic therapies aimed at resetting the methylation … the cellular functions of chromatin
methylation and focus on … genes are silenced by DNA methylation in cancer 26 . Furthermore…

… epigenetic marks make this pathway druggable, providing the basis for the design of epigenetic
therapies … is disclosing the crucial role of epigenetic alterations (ie DNA methylation, post-…

… modulation of epigenetics. In addition, we review the promise that pharmacological inhibitors
of these proteins hold as potential therapeutic agents just beginning to enter clinical trials. …

… of epigenetic therapy including the HDAC inhibitor magnesium valproate and the non-nucleoside
DNA methylation inhibitor … Regardless of the tumor type, hydralazine and valproate …

… of DNA methylation readers or MBPs and provides an updated summary of their roles in the
context of cancer. … Epigenetic therapies (“Epi-therapies”) targeting the components of the …

… together with DNA methylation constitute an ‘epigenetic code’, … epigenetic therapeutic
strategies needs to be combined with cytotoxic factors, immunotherapy, targeted kinase inhibitors…

… effectiveness of both broad and targeted epigenetic therapies. Broad-spectrum reprogrammers
include the inhibitors of DNA methyltransferase (DNMT), histone deacetylase (HDAC) …

… development for the treatment of cancers. We … inhibiting enzymes involved in the major
epigenetic modifications regulating gene expression which include DNA methyltransferases (…