… For epigenetic therapy, the main target is chemo-resistant cells. DNA methylation that occurs
at GHD CpG islands can … Inhibition of some enzymes such as DNMTs (which catalyze the …

… epigenetic hallmark in gastric cancer. The reversible nature of epigenetic alterations and
central role of DNA methylation … an opportunity for using DNMT inhibitors to enhance the …

… development for the treatment of cancers. We … inhibiting enzymes involved in the major
epigenetic modifications regulating gene expression which include DNA methyltransferases (…

… targeting DNA methyltransferase (DNMT) and … methyltransferases (HMTS)), as well as the
combination strategies of the existing epigenetic therapeutic drugs and more new therapies to …

… new insights into epigenetic therapies in clinical oncology, taking into account the crosstalk
between tumor epigenetics, … Thus, the primary biological functions of DNA methylation in the …

… 3-kinase inhibitors has demonstrated antitumor effects in preclinical studies with NHL cells
[117]. DNA methyltransferase inhibitors … , and other epigenetic therapies may exploit similar …

… emerging molecular studies elucidating how epigenetic rewiring in cancer cells may as well
exert immune-modulatory functions, … DNA methylation is a heritable epigenetic mark mainly …

… Historically, epigenetic regulation through DNA methylation was the best studied … patient
populations so that we might one day make precision epigenetic therapy a part of our treatment …

… There are other epigenetic therapies in clinical development such as EZH2 … DNA methylation
using DNMT inhibitors has changed the way we treat cancer, as it is an established therapy …

… focused on DNA Methyltransferases, their biology, their functions, and their new inhibitory
… DNMTs because they have an important role in the epigenetic regulation of living beings [14…