Nucleotide excision repair is impaired by binding of transcription factors to DNA
R Sabarinathan, L Mularoni, J Deu-Pons… - Nature, 2016 - nature.com
… To determine the impact of DNA-binding proteins on DNA repair, we analysed the somatic
… then mapped them to the TFBS centred windows, and similar to mutation and repair rates, …
… then mapped them to the TFBS centred windows, and similar to mutation and repair rates, …
[HTML][HTML] Mapping the genetic landscape of human cells
… replicative DNA damage and a synthetic-lethal interaction with the ATR/9-1-1 DNA repair …
GI maps as a high-resolution tool for dissecting gene function, and serves as a blueprint for …
GI maps as a high-resolution tool for dissecting gene function, and serves as a blueprint for …
[HTML][HTML] A novel pyrazolopyrimidine ligand of human PGK1 and stress sensor DJ1 modulates the shelterin complex and telomere length regulation
AE Bilsland, Y Liu, A Turnbull, D Sumpton… - Neoplasia, 2019 - Elsevier
… of DNA damage responses and inappropriate repair. However, … Table 1 presents data
collection and refinement statistics. … and computational fragment mapping to implicate C106 as a …
collection and refinement statistics. … and computational fragment mapping to implicate C106 as a …
CDK12 regulates DNA repair genes by suppressing intronic polyadenylation
SJ Dubbury, PL Boutz, PA Sharp - Nature, 2018 - nature.com
… this mechanism is conserved in human tumours that contain loss-of-… (ChIP), we mapped
RNAPII and Ser2p RNAPII density … Primers to Pgk1 were used as a control to compare samples …
RNAPII and Ser2p RNAPII density … Primers to Pgk1 were used as a control to compare samples …
Phosphoglycerate kinase: structural aspects and functions, with special emphasis on the enzyme from Kinetoplastea
M Rojas-Pirela, D Andrade-Alviárez… - Open …, 2020 - royalsocietypublishing.org
… Apparently, the 3′-UTR of the PGK1 gene contains a … Peptide mapping and site-directed
mutagenesis studies … capacity, improved ability to repair DNA damage and an upregulation of …
mutagenesis studies … capacity, improved ability to repair DNA damage and an upregulation of …
Regulation of the base excision DNA repair pathway is critical for proper cell function
AJ McPherson-Davie - 2020 - search.proquest.com
… , a base excision DNA repair protein, reveals novel genetic … we mapped the specific sites of
SUMO modification within Ntg1 … Estimates suggest that 90,000 oxidative lesions and 200,000 …
SUMO modification within Ntg1 … Estimates suggest that 90,000 oxidative lesions and 200,000 …
[HTML][HTML] Mechanisms of UV-induced mutations and skin cancer
GP Pfeifer - Genome instability & disease, 2020 - Springer
… causes various types of DNA damage, which leads to … of resolution, the focus of these UV
damage mapping studies … Although still associated with high sequencing costs, there are now …
damage mapping studies … Although still associated with high sequencing costs, there are now …
Measurement of Oxidative DNA Damage in the Human p53 and PGK1 Gene at Nucleotide Resolution
SA Akman, H Rodriguez - 2021 - nist.gov
… By developing an oxidative DNA damage mapping version of the Ligation Mediated … of
DNA base modifications caused by ROS in human p53 and PGK1 gene. In vivo and in vitro …
DNA base modifications caused by ROS in human p53 and PGK1 gene. In vivo and in vitro …
[HTML][HTML] Damage mapping techniques and the light they have shed on canonical and atypical UV photoproducts
KA Bohm, JJ Wyrick - Frontiers in Genetics, 2023 - frontiersin.org
… in the promoter region of the PGK1 gene in UV-irradiated cells. A … The resolution of DNA
damage mapping methods was … high-resolution (ie, single nucleotide resolution) mapping of …
damage mapping methods was … high-resolution (ie, single nucleotide resolution) mapping of …
Differential roles of the RNases H in preventing chromosome instability
AD Zimmer, D Koshland - Proceedings of the National …, 2016 - National Acad Sciences
… DNA damage can lead to chromosome instability and loss of … We then mapped the LOH in
these progeny by monitoring … regions lie within the fourth interval, one on the PGK1 gene and …
these progeny by monitoring … regions lie within the fourth interval, one on the PGK1 gene and …