Nucleotide excision repair is impaired by binding of transcription factors to DNA

R Sabarinathan, L Mularoni, J Deu-Pons… - Nature, 2016 - nature.com
… To determine the impact of DNA-binding proteins on DNA repair, we analysed the somatic
… then mapped them to the TFBS centred windows, and similar to mutation and repair rates, …

[HTML][HTML] Mapping the genetic landscape of human cells

MA Horlbeck, A Xu, M Wang, NK Bennett, CY Park… - Cell, 2018 - cell.com
… replicative DNA damage and a synthetic-lethal interaction with the ATR/9-1-1 DNA repair
GI maps as a high-resolution tool for dissecting gene function, and serves as a blueprint for …

[HTML][HTML] A novel pyrazolopyrimidine ligand of human PGK1 and stress sensor DJ1 modulates the shelterin complex and telomere length regulation

AE Bilsland, Y Liu, A Turnbull, D Sumpton… - Neoplasia, 2019 - Elsevier
… of DNA damage responses and inappropriate repair. However, … Table 1 presents data
collection and refinement statistics. … and computational fragment mapping to implicate C106 as a …

CDK12 regulates DNA repair genes by suppressing intronic polyadenylation

SJ Dubbury, PL Boutz, PA Sharp - Nature, 2018 - nature.com
… this mechanism is conserved in human tumours that contain loss-of-… (ChIP), we mapped
RNAPII and Ser2p RNAPII density … Primers to Pgk1 were used as a control to compare samples …

Phosphoglycerate kinase: structural aspects and functions, with special emphasis on the enzyme from Kinetoplastea

M Rojas-Pirela, D Andrade-Alviárez… - Open …, 2020 - royalsocietypublishing.org
… Apparently, the 3′-UTR of the PGK1 gene contains a … Peptide mapping and site-directed
mutagenesis studies … capacity, improved ability to repair DNA damage and an upregulation of …

Regulation of the base excision DNA repair pathway is critical for proper cell function

AJ McPherson-Davie - 2020 - search.proquest.com
… , a base excision DNA repair protein, reveals novel genetic … we mapped the specific sites of
SUMO modification within Ntg1 … Estimates suggest that 90,000 oxidative lesions and 200,000 …

[HTML][HTML] Mechanisms of UV-induced mutations and skin cancer

GP Pfeifer - Genome instability & disease, 2020 - Springer
… causes various types of DNA damage, which leads to … of resolution, the focus of these UV
damage mapping studies … Although still associated with high sequencing costs, there are now …

Measurement of Oxidative DNA Damage in the Human p53 and PGK1 Gene at Nucleotide Resolution

SA Akman, H Rodriguez - 2021 - nist.gov
… By developing an oxidative DNA damage mapping version of the Ligation Mediated … of
DNA base modifications caused by ROS in human p53 and PGK1 gene. In vivo and in vitro …

[HTML][HTML] Damage mapping techniques and the light they have shed on canonical and atypical UV photoproducts

KA Bohm, JJ Wyrick - Frontiers in Genetics, 2023 - frontiersin.org
… in the promoter region of the PGK1 gene in UV-irradiated cells. A … The resolution of DNA
damage mapping methods was … high-resolution (ie, single nucleotide resolution) mapping of …

Differential roles of the RNases H in preventing chromosome instability

AD Zimmer, D Koshland - Proceedings of the National …, 2016 - National Acad Sciences
DNA damage can lead to chromosome instability and loss of … We then mapped the LOH in
these progeny by monitoring … regions lie within the fourth interval, one on the PGK1 gene and …