… Oxanine (Oxa) is a significant product of guanine nitrosation by nitric oxide, nitrous acid or
N… of these enzymes may prove to be an effective novel anticancer strategy in the future. Thus, …

… transport chain, the tRNAs that mediate a separate genetic code, and … Oxanine, generated
in DNA by nitric oxide attack on guanine, traps … The DPC formed with oxanine and 5-hydroxy-5-…

… , a novel mammalian protease, SPRTN, was identified as a central player in the DPC repair
pathway. … DPC recognition and repair mechanisms to prevent DPC-induced genotoxicity. …

… describes the formation and fate of oxidative DPC formed by … Polβ-DPC in cells challenged
with genotoxic oxidants. … enters on characterizing the formation of DPC mediated by C1′ …

… Both human polymerase (hPol) κ and hPol η inserted the correct base (C) opposite the 10-mer
peptide cross-link, although small amounts of T were added by hPol η. Molecular …

… -mediated DNA- peptide cross-links are poor NER substrates, requiring a different pathway
… Construction and characterization of a plasmid containing a single DNA-peptide cross-link …

… In this study, we carried out TdT-mediated incorporation of Oxa by offering dOTP as a substrate.
… This represents a novel method of enzymatic synthesis for design of reactive-end DNA …

… synthesized and structurally characterized a novel … phenol ring to yield the stable DNA-protein
cross-link (34) …………… is 50 -100-fold more mutagenic and genotoxic than other epoxide …

… Cross-link formation is reversible and is ascribed to nucleophilic attack at the C8 position …
., DNA-protein cross-link formation mediated by oxanine. A novel genotoxic mechanism of nitric …

… complex, we developed a novel enzymatic method for single-… modified rNTPs containing an
oxanine, biotin, aminoallyl or N … concentration is mediated by the increased formation of the …