… obstructive airway disease). Due to the … a more severe clinical course with rapid decline
of lung function [66]. … Consistently in patients with DNAH5 mutations, the DNAH5 protein is …

… of disease (normal lung function [FEV 1 , FVC, FEV 1 /FVC, total lung capacity, diffusing
capacity of the lung … , and prevention of chronic obstructive pulmonary disease: GOLD executive …

… Over 50 genes have been reported to be associated with PCD, including DNAH5,
DNAH11, DNAI1, DNAI2, DNAL1, TXNDC3, DNAAF1, DNAAF2, etc. [1, 6, 11]. In 2008, two …

… 80 4.4 A subject with an atypical pathogenic variant in DNAH5 … associated with well-known
human cystic kidney diseases … , DNAH5 and DNAH11, show preserved lung function and no …

… , we first examined the function of the genes associated with the 19 rare … DNAH5, DNAH9,
and DNAH11) can cause primary ciliary dyskinesia (PCD). PCD is a severe inherited disorder …

… related respiratory symptoms or fertility problems and cannot be diagnosed as typical PCD.
The lack of respiratory … defects and universally suffer from upper and lower airway diseases. …

… This includes obstructive airway disease, low nasal NO, and … congenital heart defect
associated with heterotaxy was … and airway clearance defects seen in PCD patients with DNAH5 …

… for airway defense and are impaired in chronic obstructive … dynein axonemal heavy chain 5
(Dnah5) (Figure 4e–g). … indicated by an increase in total lung capacity and reduction in tissue …

… , such as presence of chronic obstructive pulmonary diseases or reported smoking history
… in multiple cilium-related biological processes and cellular components like DNAH5 (dynein …

… A recent GWAS identified genetic variants associated with total lung capacity in COPD [4].
Among several SNPs that were identified in patients with prominent emphysema, one was in …