… Whilst malaria incidence and mortality has decreased in the … to chloroquine in areas
where chloroquineresistant P. … failed to achieve sufficiently high cure rates (92% by Day 14 …

… There is a fear of resistant Plasmodium falciparum emerging in … falciparum parasites with
decreased susceptibility/resistance … in Gabon in children with uncomplicated malaria reported a …

… the Plasmodium falciparum chloroquine resistance transporter (Pfcrt) gene and Plasmodium
falciparum multidrug resistance … , a significant decline in the early responses of childhood P. …

Background Emergence of drug resistance demands novel antimalarial drugs with new
mechanisms of action. We aimed to identify effective and well tolerated doses of ganaplacide …

… inducing immune responses against Plasmodium falciparum (Pf) … -center, Phase I trial,
conducted in Lambaréné, Gabon [22]. Study … The other volunteer showed decreasing P. malariae …

… for uncomplicated Plasmodium falciparum malaria in virtually all … falciparum lineages within
South and Southeast Asia and … of decreasing therapeutic effectiveness, malaria cases and …

… of chloroquine resistant parasites decreased over time, after … of chloroquine for the treatment
of uncomplicated malaria [21,… falciparum clinical isolates collected in Lambaréné, Gabon …

… A further decline of treatment efficacy could result in increased … Plasmodium falciparum
chloroquine resistance transporter … for ART-MQ resistance and recrudescence [92]. Pfmdr1 …

… acquisition of drug resistance in Plasmodium falciparum is given. … responses showed a
decreased chloroquine uptake, leaving … while increasing susceptibility to mefloquine [Citation98]. …

… Plasmodium falciparum is responsible for the vast majority of … falciparum in Central African
Gabon showed that single … drug reactions and may also decrease the cost-effectiveness of …