… Our study highlights that DBS effects can go beyond regularizing … The motor symptoms
of bradykinesia and rigidity are … a population of external globus pallidus (GPe) neurons that …

… pallidus, both pars externa and pars interna (GPe-GPi), and the thalamus. Parkinsonian …
in the basal ganglia by inducing a new regularized pattern of synchronous neuronal activity. …

… of symptom alleviation in animal models of PD and the degree of bradykinesia in persons …
Analysis of oscillatory neural activity in series network models of Parkinson’s disease during …

… activity of an already hyperactive parkinsonian GPi and result in a reduction of net inhibition
to the TH and thereby reduce bradykinesia… failed to regularize GPi neural activity and restore …

… be specially puzzling given that the alleviation of the PD motor … that HFS works by regularizing
basal ganglia activity and thus … model dictates that external globus pallidus (GPe) ablation …

… to alleviate its symptoms according to the development stage of PD. Deep brain stimulation
(… In contrast, we analyze the firing activity of neuronal populations via the Hodgkin–Huxley (…

… target for deep brain stimulation (DBS) for Parkinson’s disease … -generating capacity in STN
remedies bradykinesia (21, 36), … STN neurons substantially alleviates parkinsonian deficits in …

… made on patients exhibiting a combination of bradykinesia and/or rigidity during the onset of
… The therapeutic mechanisms of DBS on neuronal activities is still not clear. Various studies …

… , giving rise to symptoms like bradykinesia, rigidity, and tremor. … the Vim is effective in
alleviating tremors, likely through … electrical subthalamic and pallidal stimulation enhances PD …

… STN DBS and levodopa alleviate some motor signs in parkinsonian mice. … In fact, one group
studying healthy NHPs has even observed positive modulation during movement in pallidal …