… of HSC and liver fibrogenesis are NOX1, NOX2, and NOX4 [55,… to p47 phox -deficient mice,
less liver damage and hepatic free … FXR activity is a major inhibitor of HCC. Whole-body FXR-…

… NOX4-deficient mice show decrease in epithelial cell … the first small molecule inhibitor
targeting NOX1/NOX4 (133). … balance through inhibition of TGF-β1-induced NOX4 activity and …

… mouse was the first genetic model of NOX inhibition … inhibitors, such as NOX1 and/or NOX4
to prevent HSC activation and protect hepatocyte injury may be promising to treat liver fibrosis…

… –2) [7], NOX1, NOX2, and NOX4 are expressed in the liver [8]. … deficiency suppresses NOX4
expression through inhibiting the … reducing ROS production and ameliorating liver fibrosis. …

… of hepatic ROS could be an effective strategy in preventing … Recently, a NOX4/NOX1 dual
inhibitor (GKT137831) has … that NOX-deficient (p47 phox −/− ) mice had a decrease of oxidative …

… Various isoforms, such as NOX1, NOX2, and NOX4, are distinctively expressed in specific
… NOX1 inhibition does not prevent HCC development in mice. In order to induce HCC, …

… inhibition or genetic deletion of NOX1 or 4 prevents fibrosis in … Deficiency of either NOX4
or NOX1 and treatment with the … to inhibit NOX1 as well as NOX4 in skin aging and fibrotic …

… -choline deficient diet) diet were used to induce liver fibrosis. … NOX has seven isoforms
(NOX1-NOX5, DUOX1 and DUOX2)… showed that NOX4 expression in mice with liver fibrosis was …

… obese-diabetic mice and choline-deficient diet-fed rats, the … HSC activation, and NOX1,
NOX2, and NOX4 are most likely the … Via inhibition of the TLR4/NF-κB pathway, hepatoprotective …

… novel strategies to prevent aging-related liver fibrosis. … is composed of the membrane subunit
(NOX1-5), p22phox and the … effect on neuronal damage via inhibition of oxidative stress-…