… Mitochondrial dysfunction that causes a decrease in ATP and/or an increase in ROS is …
of MitoQ and BGP-15 in our oxidative stress model, in-vitro matured MII oocytes from young …

… -1 promotes the deficiency of spindle assembly by disturbing … suppresses oxidative
stress and restores abnormal spindle … spindle assembly dynamics, and mitochondria-derived …

… microtubules are assembled from the opposite spindle poles … most likely is not severely
impaired due to in vitro conditions. … Oxidative stress can severely harm the oocyte’s function by …

… In addition, strong oxidative stress, such as that caused by H 2 O 2 , … spindle formation,
particularly during the MII stage of oocytes, by reducing the amount of mitochondria-derived ATP […

… , did not impair oocyte growth but blocked meiotic maturation of … oxidative stress during
oocyte and embryo in vitro culture. … around the MI spindle, which is observed in mouse oocytes. …

… As such, mitochondria derived from the oocyte serve as a … in mouse oocytes, the outcomes
showed significant spindle … safeguard mitochondria from oxidative damage and enhance their …

… of oxidative stress–induced aneuploidy following in vitro oocyte maturation, but was ineffective
for naturally aged oocytes. … Oxidative stress impairs oocyte quality and melatonin protects …

… mtDNA mutations [17]; impaired mitochondria function could, in … spindle assembly is closely
related to oxidative stress in … the three pathways (Adenosine Triphosphate (ATP), Adenosine …

… , chromosomes and spindles in mice. C57BL/6 female … past 10 years, and infertility currently
affects ~15% of females of … that oxidative stress serves an important role in oocyte ageing, …

… has been reported to impair oocyte quality in mice, however, the … spindle disorganization
and chromosome misalignment … To collect ovulated MII oocytes, mice received an injection of 5 …