Common variable immunodeficiency disorders (CVIDs) are the most frequent symptomatic
primary immune deficiencies (PIDs) in adults. Most patients suffer recurrent infections as a
consequence of immune system failure (ISF) caused by late-onset antibody failure. 1–4 A
significant minority of patients with CVID also have an increased risk of autoimmune or
inflammatory disorders because of immune dysregulation. Although many patients have
symptoms dating back to infancy, 5 most are diagnosed beyond early childhood. a …