RhoA as a target to promote neuronal survival and axon regeneration

J Hu, ME Selzer - Neural regeneration research, 2017 - journals.lww.com
… of treatments that are both neuroprotective and axon regeneration-promoting, to enhance
functional … The “bad-regenerating” RS neurons often experience very delayed retrograde …

RhoA/Rho kinase in spinal cord injury

X Wu, X Xu - Neural regeneration research, 2016 - journals.lww.com
… strategy to prevent cell death and promote axon regeneration. … also shows promise in
axonal regeneration and functional … , whereas delayed treatment at 4 weeks post-SCI was not

The effect of Rho Kinase inhibition on corneal nerve regeneration in vitro and in vivo

S Mertsch, I Neumann, C Rose, M Schargus… - The ocular …, 2021 - Elsevier
… new treatment by enhancing the corneal nerve regenerationnerve regeneration and that
gap-43 is activated in the late stage of … As nerve regeneration is often associated with functional

RhoA drives actin compaction to restrict axon regeneration and astrocyte reactivity after CNS injury

S Stern, BJ Hilton, ER Burnside, S Dupraz, EE Handley… - Neuron, 2021 - cell.com
… prevent axons from regenerating in the adult central nervous system (CNS). Here we show
how the two aspects are interwoven. Genetic loss-of-function experiments determine that the …

Advances in the signaling pathways downstream of glial-scar axon growth inhibitors

A Sami, ME Selzer, S Li - Frontiers in cellular neuroscience, 2020 - frontiersin.org
… PNNs are formed during late stages of CNS development … , inhibit Rho activity independently
of their classical function as the inhibitors of cyclooxygenases and promote axon regrowth

RhoA inhibitor treatment at acute phase of spinal cord injury may induce neurite outgrowth and synaptogenesis

S Devaux, D Cizkova, K Mallah, MA Karnoub… - Molecular & Cellular …, 2017 - ASBMB
… turn may lead to higher assumption for functional improvement. Among the inhibitory factors
that prevent axonal regrowth in … In particular, we show that RhoAi is able to promote neurite …

Advantages of Rho-associated kinases and their inhibitor fasudil for the treatment of neurodegenerative diseases

Q Wang, LJ Song, ZB Ding, Z Chai, JZ Yu… - Neural regeneration …, 2022 - journals.lww.com
… the therapeutic effects of Rho kinase inhibitors, particularly fasudil, … that inhibition of ROCKs
activity promotes nerve regeneration … They inhibit the function of Th1 and Th17 cells and M1 …

The role of RhoA in retrograde neuronal death and axon regeneration after spinal cord injury

J Hu, G Zhang, W Rodemer, LQ Jin, M Shifman… - Neurobiology of …, 2017 - Elsevier
… target Rho kinase (ROCK) with Y-27632, has enhanced … C3 or Y-27632 treatment was
sufficient to promote functional … axotomized, that the delayed neuronal death was due to the …

Strategies to neutralize RhoA/ROCK pathway after spinal cord injury

A Roy, Z Pathak, H Kumar - Experimental Neurology, 2021 - Elsevier
… Loss of OMgp has been shown to promote functionalnerve injury and inhibit axon
regeneration in the optic nerve. … Upon the activation of Rho-kinase by Rho during the action of …

Blockade of Rho-associated kinase prevents inhibition of axon regeneration of peripheral nerves induced by anti-ganglioside antibodies

A Berardo, CR Bacaglio, BB Báez… - Neural Regeneration …, 2024 - journals.lww.com
… of unmyelinated fibers to skin and the functional recovery of … Delayed or deficient target
reinnervation usually results from … potential targets for improving axon regeneration in the CNS, …