RhoA as a target to promote neuronal survival and axon regeneration
… of treatments that are both neuroprotective and axon regeneration-promoting, to enhance
functional … The “bad-regenerating” RS neurons often experience very delayed retrograde …
functional … The “bad-regenerating” RS neurons often experience very delayed retrograde …
RhoA/Rho kinase in spinal cord injury
… strategy to prevent cell death and promote axon regeneration. … also shows promise in
axonal regeneration and functional … , whereas delayed treatment at 4 weeks post-SCI was not …
axonal regeneration and functional … , whereas delayed treatment at 4 weeks post-SCI was not …
The effect of Rho Kinase inhibition on corneal nerve regeneration in vitro and in vivo
S Mertsch, I Neumann, C Rose, M Schargus… - The ocular …, 2021 - Elsevier
… new treatment by enhancing the corneal nerve regeneration … nerve regeneration and that
gap-43 is activated in the late stage of … As nerve regeneration is often associated with functional …
gap-43 is activated in the late stage of … As nerve regeneration is often associated with functional …
RhoA drives actin compaction to restrict axon regeneration and astrocyte reactivity after CNS injury
S Stern, BJ Hilton, ER Burnside, S Dupraz, EE Handley… - Neuron, 2021 - cell.com
… prevent axons from regenerating in the adult central nervous system (CNS). Here we show
how the two aspects are interwoven. Genetic loss-of-function experiments determine that the …
how the two aspects are interwoven. Genetic loss-of-function experiments determine that the …
Advances in the signaling pathways downstream of glial-scar axon growth inhibitors
A Sami, ME Selzer, S Li - Frontiers in cellular neuroscience, 2020 - frontiersin.org
… PNNs are formed during late stages of CNS development … , inhibit Rho activity independently
of their classical function as the inhibitors of cyclooxygenases and promote axon regrowth …
of their classical function as the inhibitors of cyclooxygenases and promote axon regrowth …
RhoA inhibitor treatment at acute phase of spinal cord injury may induce neurite outgrowth and synaptogenesis
… turn may lead to higher assumption for functional improvement. Among the inhibitory factors
that prevent axonal regrowth in … In particular, we show that RhoAi is able to promote neurite …
that prevent axonal regrowth in … In particular, we show that RhoAi is able to promote neurite …
Advantages of Rho-associated kinases and their inhibitor fasudil for the treatment of neurodegenerative diseases
Q Wang, LJ Song, ZB Ding, Z Chai, JZ Yu… - Neural regeneration …, 2022 - journals.lww.com
… the therapeutic effects of Rho kinase inhibitors, particularly fasudil, … that inhibition of ROCKs
activity promotes nerve regeneration … They inhibit the function of Th1 and Th17 cells and M1 …
activity promotes nerve regeneration … They inhibit the function of Th1 and Th17 cells and M1 …
The role of RhoA in retrograde neuronal death and axon regeneration after spinal cord injury
J Hu, G Zhang, W Rodemer, LQ Jin, M Shifman… - Neurobiology of …, 2017 - Elsevier
… target Rho kinase (ROCK) with Y-27632, has enhanced … C3 or Y-27632 treatment was
sufficient to promote functional … axotomized, that the delayed neuronal death was due to the …
sufficient to promote functional … axotomized, that the delayed neuronal death was due to the …
Strategies to neutralize RhoA/ROCK pathway after spinal cord injury
… Loss of OMgp has been shown to promote functional … nerve injury and inhibit axon
regeneration in the optic nerve. … Upon the activation of Rho-kinase by Rho during the action of …
regeneration in the optic nerve. … Upon the activation of Rho-kinase by Rho during the action of …
Blockade of Rho-associated kinase prevents inhibition of axon regeneration of peripheral nerves induced by anti-ganglioside antibodies
A Berardo, CR Bacaglio, BB Báez… - Neural Regeneration …, 2024 - journals.lww.com
… of unmyelinated fibers to skin and the functional recovery of … Delayed or deficient target
reinnervation usually results from … potential targets for improving axon regeneration in the CNS, …
reinnervation usually results from … potential targets for improving axon regeneration in the CNS, …