[HTML][HTML] Mitigation of ALS pathology by neuron-specific inhibition of nuclear factor kappa B signaling
K Dutta, SS Thammisetty, H Boutej… - Journal of …, 2020 - Soc Neuroscience
… -κB activity in pathogenesis of amyotrophic lateral sclerosis (… in mice expressing TDP-43
A315T or TDP-43 G348C mice … remained unknown whether deregulated NF-κB signaling within …
A315T or TDP-43 G348C mice … remained unknown whether deregulated NF-κB signaling within …
[HTML][HTML] TDP-43 and inflammation: implications for amyotrophic lateral sclerosis and frontotemporal dementia
… the relationship between TDP-43 and immune-mediated pathways. … and the deregulation
of TDP-43 may contribute to ALS … TDP-43 and trigger the inflammatory response observed in …
of TDP-43 may contribute to ALS … TDP-43 and trigger the inflammatory response observed in …
[HTML][HTML] The overexpression of TDP-43 in astrocytes causes neurodegeneration via a PTP1B-mediated inflammatory response
S Lee, S Kim, HY Kang, HR Lim, Y Kwon, M Jo… - Journal of …, 2020 - Springer
… Cytoplasmic inclusions of transactive response DNA binding protein of 43 kDa (TDP-43) in
… TDP-43 (FTLD-TDP) and amyotrophic lateral sclerosis (ALS). However, the role of TDP-43 in …
… TDP-43 (FTLD-TDP) and amyotrophic lateral sclerosis (ALS). However, the role of TDP-43 in …
Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis
K Oiwa, S Watanabe, K Onodera, Y Iguchi… - Science …, 2023 - science.org
… from the TDP-43 monomers function as seeds and trigger coaggregation and sequestration
of … of TDP-43 WT – and TDP-43 6M –mediated toxicities, we assessed the splicing function of …
of … of TDP-43 WT – and TDP-43 6M –mediated toxicities, we assessed the splicing function of …
[HTML][HTML] Age-related deregulation of TDP-43 after stroke enhances NF-κB-mediated inflammation and neuronal damage
SS Thammisetty, J Pedragosa, YC Weng… - Journal of …, 2018 - Springer
… TDP-43 may trigger activation of NF-κB … a TDP-43-mediated deregulation and activation
of NF-κB pathway. We measured the nuclear phosphorylation levels of P65 subunit of NF-κB …
of NF-κB pathway. We measured the nuclear phosphorylation levels of P65 subunit of NF-κB …
[HTML][HTML] TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes
TJ LaRocca, A Mariani, LR Watkins, CD Link - Neurobiology of disease, 2019 - Elsevier
… TDP-43) is a multifunctional RNA binding protein directly implicated in the etiology of amyotrophic
lateral sclerosis (ALS… pro-inflammatory transcription factor nuclear factor kappa B (NF-…
lateral sclerosis (ALS… pro-inflammatory transcription factor nuclear factor kappa B (NF-…
[HTML][HTML] Evidence of A negative feedback network between TDP-43 and miRNAs dependent on TDP-43 nuclear localization
ZCE Hawley, D Campos-Melo, MJ Strong - Journal of Molecular Biology, 2020 - Elsevier
… motor neurons of patients with amyotrophic lateral sclerosis (ALS) where TDP-43 re-locates
from … Further, we showed an induced cellular stress which causes reduced TDP-43 nuclear …
from … Further, we showed an induced cellular stress which causes reduced TDP-43 nuclear …
Why TDP-43? Why not? Mechanisms of metabolic dysfunction in amyotrophic lateral sclerosis
ML Floare, SP Allen - Neuroscience Insights, 2020 - journals.sagepub.com
… TDP-43 could also have a contribution to this deregulation of … well-known genetic causes
of ALS such as the superoxide … TDP-43 is not a requisite for TDP-43-mediated toxicity in ALS…
of ALS such as the superoxide … TDP-43 is not a requisite for TDP-43-mediated toxicity in ALS…
[HTML][HTML] IκB kinase phosphorylates cytoplasmic TDP-43 and promotes its proteasome degradation
Y Iguchi, Y Takahashi, J Li, K Araki, Y Amakusa… - Journal of Cell …, 2024 - rupress.org
… feature common to amyotrophic lateral sclerosis (ALS) and … Most signals that trigger the
NF-κB signaling pathway converge on … CUL2-mediated clearance of misfolded TDP-43 is …
NF-κB signaling pathway converge on … CUL2-mediated clearance of misfolded TDP-43 is …
TDP-43 triggers immune response via mitochondrial DNA release
… diseases including amyotrophic lateral sclerosis (ALS), … Moreover, TDP-43 deregulation
can also provoke hyperactive … from this new TDP-43-mediated pathogenic pathway. One …
can also provoke hyperactive … from this new TDP-43-mediated pathogenic pathway. One …