Design, synthesis, and biological evaluation of tetrahydroisoquinoline-based diaryl urea derivatives for suppressing VEGFR-2 signaling
Y Huang, Y Zhang, J Li, X Ma, M Hu, Y Yang… - Anti-Cancer …, 2019 - journals.lww.com
… novel modulators of VEGFR-2 signaling, the pharmacorphore-combination strategy was
introduced by incorporating diaryl urea … evaluated their capability to interfering with VEGFR-2 …
introduced by incorporating diaryl urea … evaluated their capability to interfering with VEGFR-2 …
Design, synthesis and docking study of novel picolinamide derivatives as anticancer agents and VEGFR-2 inhibitors
… urea) derivatives and their inhibitory activity against VEGFR-2 revealed that substituted
phenyl urea derivatives … than the phenyl urea derivative 7a as VEGFR-2 inhibitors. Moreover, …
phenyl urea derivatives … than the phenyl urea derivative 7a as VEGFR-2 inhibitors. Moreover, …
Facile one-pot sequential synthesis of novel diaryl urea derivatives and evaluation of their in vitro cytotoxicity on adenocarcinoma cells
F Azimian, M Hamzeh-Mivehroud… - Medicinal Chemistry …, 2021 - Springer
… , among which VEGFR-2 plays a significant role [5]. Discovery of VEGFR-2 inhibitors capable
of … Structurally diverse VEGFR-2 inhibitors (ATP analogs) with anti-angiogenic activity have …
of … Structurally diverse VEGFR-2 inhibitors (ATP analogs) with anti-angiogenic activity have …
Design, synthesis, antitumor, and VEGFR-2 inhibition activities of novel 4-anilino-2-vinyl-quinazolines: Molecular modeling studies
… The NH linker and the biphenyl thiourea in the compound 8h were well aligned with the
hot spots in sorafenib, including the O linker and the biphenyl urea moieties. The quinazoline …
hot spots in sorafenib, including the O linker and the biphenyl urea moieties. The quinazoline …
Identification of new pyrrolo [2, 3-d] pyrimidines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, biological evaluation and molecular modeling
… ring, The O or NH linkers and the biphenyl urea in the designed compounds were aligned
with the terminal phenyl ring, the O linker and the biphenyl urea moieties in both sorafenib and …
with the terminal phenyl ring, the O linker and the biphenyl urea moieties in both sorafenib and …
Design, synthesis, biological evaluation and molecular modeling of novel 1H-pyrazolo [3, 4-d] pyrimidine derivatives as BRAFV600E and VEGFR-2 dual inhibitors
Y Wang, S Wan, Z Li, Y Fu, G Wang, J Zhang… - European Journal of …, 2018 - Elsevier
… for VEGFR-2 inhibition in addition to BRAF V600E inhibition, we docked 1 into the co-crystal
structure of Sorafenib and VEGFR-2 to … The diaryl urea portion extended into the large …
structure of Sorafenib and VEGFR-2 to … The diaryl urea portion extended into the large …
… of novel pyrazole based Urea/Thiourea derivatives as multiple targeting VEGFR-2, EGFRWT, EGFRT790M tyrosine kinases and COX-2 Inhibitors, with anti-cancer …
WAA Fadaly, MTM Nemr, NM Kahk - Bioorganic Chemistry, 2024 - Elsevier
… synthesis of a set of biphenyl urea/thiourea derivatives (8a-e) linked to hetero-arylsulfonamide
motif as novel VEGFR-2 inhibitors, … scope of design, synthesis and biological evaluation of …
motif as novel VEGFR-2 inhibitors, … scope of design, synthesis and biological evaluation of …
Synthesis, biological evaluation, and molecular docking of new series of antitumor and apoptosis inducers designed as VEGFR-2 inhibitors
AE Abdallah, RR Mabrouk, MMS Al Ward… - … of Enzyme Inhibition …, 2022 - Taylor & Francis
… Urea as well as amide moiety was found to be effective … VEGFR-2 inhibitor drugs as
Regorafenib and Sunitinib, respectively ( Figure 1) . So that urea and amide moieties were designed …
Regorafenib and Sunitinib, respectively ( Figure 1) . So that urea and amide moieties were designed …
Design, synthesis and evaluation of novel thienopyrimidine-based agents bearing diaryl urea functionality as potential inhibitors of angiogenesis
A Faraji, TO Bakhshaiesh, Z Hasanvand… - European Journal of …, 2021 - Elsevier
… -aryl urea derivatives 11a-m to evaluate their efficacy in the … blood vessels, and inhibition
of VEGFR-2 phosphorylation were … of novel drugs to treat tumors, particularly prostate cancer. …
of VEGFR-2 phosphorylation were … of novel drugs to treat tumors, particularly prostate cancer. …
Design, synthesis and biological evaluation of phenylpicolinamide sorafenib derivatives as antitumor agents
C Wu, S Xu, Y Guo, J Wu, R Luo, W Wang, Y Tu… - Medicinal Chemistry …, 2018 - Springer
… In summary, two series of phenylpicolinamide sorafenib derivatives were designed and
synthesized. All the target compounds were evaluated against three cancer cell lines, VEGFR2/…
synthesized. All the target compounds were evaluated against three cancer cell lines, VEGFR2/…