Peptide-based stealth nanoparticles for targeted and pH-triggered delivery

A Ranalli, M Santi, L Capriotti, V Voliani… - Bioconjugate …, 2017 - ACS Publications
selective delivery requires the insertion of natural (antibodies, ligands, or proteins) or synthetic
(aptamers or peptides) biomolecules able to perform selective … To this end, we designed a …

Microenvironment pH-induced selective cell death for potential cancer therapy using nanofibrous self-assembly of a peptide amphiphile

S Yamamoto, K Nishimura, K Morita… - …, 2021 - ACS Publications
… Here, we report selective cell death induced by a novel peptide amphiphile that self-… pH
(pH i ). We found that a palmitoylated hexapeptide (C 16 -VVAEEE) formed a hydrogel below pH

Acid-induced activated cell-penetrating peptide-modified cholesterol-conjugated polyoxyethylene sorbitol oleate mixed micelles for pH-triggered drug release and …

Y Tian, G Mi, Q Chen, B Chaurasiya, Y Li… - … applied materials & …, 2018 - ACS Publications
… a “smart”, multifunctional polymeric micelle was developed using … activated cell-penetrating
peptide (RG) 5 at physiological pH, ie, limiting internalization, and were selectively triggered

Reconfigurable peptide nanotherapeutics at tumor microenvironmental pH

ZY Qiao, WJ Zhao, YJ Gao, Y Cong… - … applied materials & …, 2017 - ACS Publications
activated nanotherapeutics in the tumor microenvironment. Two peptides, that is, a pH-responsive
peptide HLAH and a matrix metalloprotease-2 (MMP2)-sensitive peptide with a poly(…

Design, synthesis, and evaluation of homochiral peptides containing arginine and histidine as molecular transporters

NS El-Sayed, T Miyake, AN Shirazi, SE Park, J Clark… - Molecules, 2018 - mdpi.com
… , and finally designed peptides or chimeric peptides, which … and the lack of selectivity are
the main obstacles that hinder … permit their use for developing multifunctional CPPs that vary in …

Arginine-rich ionic complementary peptides as potential drug carriers: Impact of peptide sequence on size, shape and cell specificity

Z Wan, S Lu, D Zhao, Y Ding, P Chen - … : Nanotechnology, Biology and …, 2016 - Elsevier
… of noncovalent interactions, molecular self-assembly design provides a versatile tool to tailor
the properties of self-assembled nanocarriers for optimizing the delivery of drugs.5, 7, 9, 10 …

Designing Stimuli-Responsive Amino Acid and Peptide Hydrogel Biomaterials as Functional Entrapment Matrices

N Falcone - 2021 - search.proquest.com
… the synthesis and characterization of stimuli-responsive gels. Here, we provide an understanding
of the self-assembly process of peptide conjugates and the characterization tools used …

pH-controlled chiral packing and self-assembly of a coumarin tetrapeptide

MKL Mason, RF Lalisse, TJ Finnegan, CM Hadad… - Langmuir, 2019 - ACS Publications
… to the peptide using standard peptide coupling conditions (DIPEA… The crude peptides were
precipitated with diethyl ether and … on a preparative Waters XBridge C8 column, eluting with a …

Short and robust anti-infective lipopeptides engineered based on the minimal antimicrobial peptide KR12 of human LL-37

J Lakshmaiah Narayana, R Golla, B Mishra… - ACS infectious …, 2021 - ACS Publications
… -37 lipopeptides with high selectivity, stability, and antimicrobial … peptides: C10-KR8 and
C8-KR10 (Table 1), a recent study found an optimal peptide when KR12 is conjugated with C8. (…

Tumor-homing, pH-and ultrasound-responsive polypeptide-doxorubicin nanoconjugates overcome doxorubicin resistance in cancer therapy

Z Wang, Q He, W Zhao, J Luo, W Gao - Journal of Controlled Release, 2017 - Elsevier
… -DOX) are designed by site-specific conjugation of DOX to a genetically engineered
polypeptide LHRH-ELP-C8 (Scheme 1a and b). LHRH is a peptide ligand of luteinizing hormone …