Magnetic resonance imaging Locus Coeruleus abnormality in amnestic Mild Cognitive Impairment is associated with future progression to dementia
… in demented patients. Such a reduction was not detected in Mild Cognitive Impairment
individuals… Clinical and cognitive changes occurring in AD patients have been associated with LC …
individuals… Clinical and cognitive changes occurring in AD patients have been associated with LC …
Altered structural covariance of locus coeruleus in individuals with significant memory concern and patients with mild cognitive impairment
Y Tang, M Cao, Y Li, Y Lin, X Wu, M Chen… - Cerebral …, 2023 - academic.oup.com
… changes and their association with cognitive function were explored in the SMC and MCI
groups. The purpose of this study was to explore the changes … detection of people at risk of AD. …
groups. The purpose of this study was to explore the changes … detection of people at risk of AD. …
Investigation of the functional pathogenesis of mild cognitive impairment by localisation‐based locus coeruleus resting‐state fMRI
T Liebe, M Dordevic, J Kaufmann… - Human brain …, 2022 - Wiley Online Library
… locus coeruleus (LC) is a promising target for early diagnosis because of its early structural
alterations and its relationship to the functional disturbances in the patients. In … an increase of …
alterations and its relationship to the functional disturbances in the patients. In … an increase of …
Mild cognitive impairment in de novo Parkinson's disease: a neuromelanin MRI study in locus coeruleus
Y Li, C Wang, J Wang, Y Zhou, F Ye… - Movement …, 2019 - Wiley Online Library
… patients with de novo PD with mild cognitive impairment (n = … The diagnosis of PD was made
according to the Movement … NM changes in the LC contribute to executive function deficits …
according to the Movement … NM changes in the LC contribute to executive function deficits …
[HTML][HTML] Locus coeruleus MRI contrast is reduced in Alzheimer's disease dementia and correlates with CSF Aβ levels
MJ Betts, A Cardenas-Blanco, M Kanowski… - … & Dementia: Diagnosis …, 2019 - Elsevier
… the DZNE Longitudinal Cognitive Impairment and Dementia … subjective cognitive decline, 16
with mild cognitive impairment… changes in individuals with subjective cognitive decline (SCD…
with mild cognitive impairment… changes in individuals with subjective cognitive decline (SCD…
Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases
… change with disease progression, in vivo measures of locus … Lewy bodies, MSA and mild
cognitive impairment; 75.7% and … diagnosis, respectively. Interestingly, iRBD is associated with …
cognitive impairment; 75.7% and … diagnosis, respectively. Interestingly, iRBD is associated with …
[HTML][HTML] Decreased locus coeruleus signal associated with Alzheimer's disease based on neuromelanin-sensitive magnetic resonance imaging technique
M Li, S Liu, H Zhu, Z Guo, Y Zhi, R Liu, Z Jiang… - Frontiers in …, 2022 - frontiersin.org
… was used to detect the changes of the locus coeruleus (LC) … 27 patients with AD, 15 patients
with mild cognitive impairment (… of locus coeruleus signal contrast ratios in the diagnosis of …
with mild cognitive impairment (… of locus coeruleus signal contrast ratios in the diagnosis of …
MRI‐assessed locus coeruleus integrity is heritable and associated with multiple cognitive domains, mild cognitive impairment, and daytime dysfunction
… scans of the locus coeruleus, and subsets of individuals with a diagnosis of cognitively normal,
… adult general cognitive ability (GCA) so that MCI would reflect change from prior level of …
… adult general cognitive ability (GCA) so that MCI would reflect change from prior level of …
[HTML][HTML] Lower novelty-related locus coeruleus function is associated with Aβ-related cognitive decline in clinically healthy individuals
PC Prokopiou, N Engels-Domínguez, KV Papp… - Nature …, 2022 - nature.com
… the early detection of AD-related cognitive decline and provide … participants and mild
cognitively impaired (MCI) patients. In … that these LC-network changes that we observed were …
cognitively impaired (MCI) patients. In … that these LC-network changes that we observed were …
[HTML][HTML] Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer's disease
… to detect pathology-related changes in the noradrenergic system in vivo, several studies
compared patients … mutation carriers that show cognitive impairments based on the Washington …
compared patients … mutation carriers that show cognitive impairments based on the Washington …