… immunofluorescent staining of pancreas tissue either at the time of diabetes diagnosis or
30 … necessary for tolerance induction (16). Two important considerations for the use of p:MHC-…

… pancreas-draining lymph nodes and islets in type 1 diabetes. … :R3-Treg treated mice maintain
normal beta cell function. … Tregs are primary cells from transgenic mice, whereas InsB:R3-…

… diabetes we observed that even though diabetes does not … , co-housed with knockout or
transgenic mice, were used as … + cells than that observed on beta cells, where MHC class II was …

… type 1 diabetes of nonobese-diabetic mice. For this, Reg3g gene was overexpressed in
pancreatic islets, and conferred beneficial effects on β cell … the Janus kinase 2/signal transducer …

… and peripheral tolerance of T and B cells in NOD mice with … immune tolerance in NOD mice
with late-stage diabetes. We … all of the T cells in those transgenic mice are the transgenic …

… autoimmune destruction of pancreatic beta cells and loss of … environmental factors break
tolerance of T and B cells to islet … -γ signalling in beta cells inhibited MHC class II upregulation. …

… Autoimmune type 1 diabetes (T1D) is caused by T cell mediated destruction of … beta cells
of the islets of Langerhans in the pancreas. Regulatory T cells (Tregs), defined by expression of …

… Development of an HLA-B*39:06–transgenic mouse model is … T cells and an increased
percentage of B cells and CD4 T … two (28), we considered it unlikely that insufficient pancreatic …

… cells (APC) that include B cells, macrophages, and dendritic … lack expression of MHC class
II molecules, pancreatic β cells … presence of APC expressing MHC molecules other than those …

… repertoire of specific T and B cells. A large number of these … antigen-specific T cells, pancreatic
islet inflammation (insulitis… observation from a TCR transgenic mouse model of multiple …