… of the nuclear enzyme poly (ADP-ribose) polymerase (PARP)… infarction and cerebrovascular
disease manifesting as stroke … the accumulation of diabetes-induced oxidation/peroxidation …

… Here, we offer a comprehensive review of PTMs and their roles in common metabolic
diseases and pathological consequences, including diabetes, obesity, fatty liver diseases, …

… are cation channels activated by oxidative stress and ADP-ribose (ADPR). Role of TRPM2
channels has been postulated in several neurological disorders, but, it has not been explored …

… Vascular regulation in the cerebral circulation can be impaired by inducing NSS damage
to … PARP-1 uses NAD + as substrate to form poly-ADP-ribose and plays a role in numerous …

… , such as loss of memory, defects in executive functions, and neuronal death, which mainly
occurs in the cerebral cortex and hippocampus during the later stages of this disease [31]. An …

… diabetes-induced human coronary artery smooth muscle cells [10]. These studies reveal the
significant role of microcirculation disorders … treatment of cardio-cerebral vascular diseases […

… study support the idea that diabetes induced cerebrovascular dysfunction involving the ET-1
… of blood glucose levels, 2) diabetes-induced basilar artery hypercontractility to ET-1 can be …

… role in cerebrovascular injury. Specifically, Qiu and coworkers showed that in mice with
experimental middle cerebral … -6, TNF-α), activation of poly(ADP ribose) polymerase (PARP) and …

… Damaged mitochondria DNA activates the (poly ADP-ribose) PARP-1 pathway in the
nucleus of endothelial cells, further leading to inhibition of Glyceraldehyde-3-Phosphate …

… [34] determined that diabetes-induced oxidative stress originates from the photoreceptors …
of poly (ADP-ribose) polymerases (PARPs), a family of proteins best known for their role in …