The distribution, metabolism, and excretion of trichothecene mycotoxins

SP Swanson, RA Corley - … Mycotoxicosis Pathophysiologic Effects …, 2017 - taylorfrancis.com
variations in xenobiotic metabolism have been documented. Major differences may result
from … have occurred from rapid absorption and distribution of the toxin from the gastrointestinal …

Gills as a glutathione-dependent metabolic barrier in Pacific oysters Crassostrea gigas: Absorption, metabolism and excretion of a model electrophile

R Trevisan, DF Mello, G Delapedra, DGH Silva, M Arl… - Aquatic Toxicology, 2016 - Elsevier
… for phase II xenobiotic metabolism and excretion in bivalves. … Thus, it is essential to
characterize how different organs … The data from this study reinforce the idea of a central role of …

Absorption, distribution, metabolism and excretion (ADME) of the ALK inhibitor alectinib: results from an absolute bioavailability and mass balance study in healthy …

PN Morcos, L Yu, K Bogman, M Sato, H Katsuki… - Xenobiotica, 2017 - Taylor & Francis
from this study and allow for a comprehensive understanding of the absorption, distribution,
… The difference between 84% of the parent eliminated and 75% of unabsorbed dose is 9%, …

Disposition and Fate of Toxicants

PK Gupta, PK Gupta - Concepts and Applications in Veterinary Toxicology …, 2019 - Springer
absorption, distribution, metabolism/biotransformation, and excretion (ADME) of xenobiotics
… Significant differences in metabolic mechanisms exist between species. For example, …

Absorption, distribution, metabolism, and excretion of [14C]‐dasotraline in humans

YL Chen, E Skende, J Lin, Y Yi… - Pharmacology …, 2017 - Wiley Online Library
absorbed, and extensively metabolized by oxidation and subsequent phase II conjugations.
The findings from this study also demonstrated that metabolismdifference in elimination t 1/…

Specific features of pharmacokinetics in children

P Matalová, K Urbánek… - Drug metabolism reviews, 2016 - Taylor & Francis
… drugs and other xenobiotics from cells under physiological as … differences were observed
among the age categories from 7 … route of metabolism and excretion of the drug, its distribution

[PDF][PDF] Drug biotransformation

MA Correia - Basic & clinical pharmacology, 2018 - academia.edu
… compounds called xenobiotics—substances absorbed across the … different patients because
of individual differences in drug distribution and rates of drug metabolism and elimination

Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans

P Schlosser, Y Li, P Sekula, J Raffler… - Nature …, 2020 - nature.com
from continuous systemic processes related to the absorption… of 1,172 endogenous and
xenobiotic metabolites, replicate … differences, but our current study cannot distinguish between

Effects of Xenobiotics on Nutrition

P Xu - Nutritional Toxicology, 2022 - Springer
… affect each other from the steps of digestion, absorption, metabolism, and excretion. Here,
we … of toxicants on nutrients takes place at different stages, including absorption, distribution, …

Biotransformation of xenobiotics in living systems—metabolism of drugs: Partnership of liver and gut microflora

M Đanić, M Mikov - Pharmaceutical biocatalysis, 2020 - taylorfrancis.com
… of a xenobiotic from those favoring absorption (lipophilicity) … Potential impacts of species
differences in drug metabolism … Finally, the conjugated xenobiotics are being excreted out by …