[HTML][HTML] Assessment of veterinary drugs in plants using pharmacokinetic approaches: The absorption, distribution and elimination of tetracycline and sulfamethoxazole …

HR Chen, T Rairat, SH Loh, YC Wu, TW Vickroy… - Plos one, 2017 - journals.plos.org
… The elimination mechanism of xenobiotics in plants is anatomically different from those of
animals. Unlike most animal species, vegetables have no specific organs for drug …

[HTML][HTML] Systematic review of physiologically based kinetic lactation models for transfer of xenobiotic compounds to milk

IR Dubbelboer, L Le Roux-Pullen, R Gehring - Toxicology and Applied …, 2023 - Elsevier
… described the lactational elimination of xenobiotic compounds in … of the absorption, distribution,
metabolism and excretion (ADME) of … as the difference in concentration between these …

Mussel digestive gland as a model tissue for assessing xenobiotics: an overview

C Faggio, V Tsarpali, S Dailianis - Science of the Total Environment, 2018 - Elsevier
… the effects of different categories of xenobiotic compounds, previously … of mussels have low
metabolic and excretion rates, thus this … compounds from each class of those xenobiotics are …

[HTML][HTML] Predicting drug extraction in the human gut wall: assessing contributions from drug metabolizing enzymes and transporter proteins using preclinical models

SA Peters, CR Jones, AL Ungell, OJD Hatley - Clinical pharmacokinetics, 2016 - Springer
… plasma ratio deviates significantly from unity [46]; or (3) first-order elimination is not conserved
at … differences in drug uptake into enterocytes, efflux and intestinal metabolism arising from

Xenobiotics metabolization in Salix alba leaves uncovered by mass spectrometry imaging

C Villette, L Maurer, A Wanko, D Heintz - Metabolomics, 2019 - Springer
… of leaf sections from S. alba revealed different distribution patterns of xenobiotics in the leaf
… tract and excreted in wastewater (after a drug treatment for example), or the presence of …

The role of the kidney in drug elimination: transport, metabolism, and the impact of kidney disease on drug clearance

JO Miners, X Yang, KM Knights… - Clinical Pharmacology & …, 2017 - Wiley Online Library
… for the elimination of a myriad of drugs, nondrug xenobiotics, … Disparities are apparent in the
results from investigations … decreased liver uptake, and decreased biliary/renal excretion, all …

Comparative toxicokinetics of Fusarium mycotoxins in pigs and humans

W Schelstraete, M Devreese, S Croubels - Food and chemical toxicology, 2020 - Elsevier
… metabolite and excretion patterns are observed, although some quantitative differences are
noticed … DON exposure can potentially affect its own absorption and that of other xenobiotics. …

… extraction of metabolite information of drug candidates: analysis of 27 AstraZeneca compounds with human absorption, distribution, metabolism, and excretion data

J Iegre, MA Hayes, RA Thompson, L Weidolf… - Drug Metabolism and …, 2016 - ASPET
… of significantly different metabolite profiles between species … role is either to uptake xenobiotics
from the primary urine into … Different substrate specificity between otherwise similar drug-…

… ‐derived nanovesicles as liquid biopsy; has the golden age of translational pharmacokinetics‐absorption, distribution, metabolism, excretion‐drug–drug interaction …

D Rodrigues, A Rowland - Clinical Pharmacology & …, 2019 - Wiley Online Library
… Examples 5–7 in Table 3 relate to xenobiotic-dependent modulation of DME and transporter
expression in different organs. For example, smoking has been shown to impact trait …

The role of xenobiotic-metabolizing enzymes in the placenta: a growing research field

R Blanco-Castañeda… - Expert review of …, 2020 - Taylor & Francis
… The placenta performs metabolic and excretion functions, on … histological differences of the
human placental structure from … once this drug is uptake from maternal circulation to placenta …