Differential contribution of estrogen receptors to the intestinal therapeutic effects of 17β-estradiol in a murine model of Parkinson's disease
AA Poirier, M Côté, M Bourque, H Jarras… - Brain Research …, 2022 - Elsevier
Beneficial effects of estrogens have been reported in Parkinson's disease (PD) for many
years. We previously reported their neuroprotective and anti-inflammatory potentials in the
enteric nervous system of the intestine, a region possibly affected during the early stages of
the disease according to Braak's hypothesis. Three different estrogen receptors have been
characterized to date: the estrogen receptor alpha (ERα), the estrogen receptor beta (ERβ)
and the G protein coupled estrogen receptor 1 (GPER1). The aim of the present study was to …
years. We previously reported their neuroprotective and anti-inflammatory potentials in the
enteric nervous system of the intestine, a region possibly affected during the early stages of
the disease according to Braak's hypothesis. Three different estrogen receptors have been
characterized to date: the estrogen receptor alpha (ERα), the estrogen receptor beta (ERβ)
and the G protein coupled estrogen receptor 1 (GPER1). The aim of the present study was to …
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