Beryllium-induced hypersensitivity: genetic susceptibility and neoantigen generation

AP Fontenot, MT Falta, JW Kappler, S Dai… - The Journal of …, 2016 - journals.aai.org
… that may have important contributions to disease pathogenesis. … A differential risk for disease
development was associated with … of beryllium sensitivity and chronic beryllium disease. …

HLA-DPB1 E69 genotype and exposure in beryllium sensitisation and disease

J Crooks, MM Mroz, M VanDyke, A McGrath… - Occupational and …, 2022 - oem.bmj.com
beryllium exposure individually contribute to risk of chronic … were likely affected by differential
exposure misclassification. The … . Chronic beryllium disease and sensitization at a beryllium

Research to practice implications of high-risk genotypes for beryllium sensitization and disease

K Kreiss, ED Fechter-Leggett… - … of occupational and …, 2016 - journals.lww.com
… workers may better understand their genetic susceptibility to chronic beryllium disease (CBD…
we contributed to a multi-institutional case-control study. Unlike the other contributed studies…

[PDF][PDF] Beryllium-Induced Hypersensitivity: Genetic

S Dai, AS McKee, AP Fontenot, MT Falta, JW Kappler - J Immunol, 2016 - researchgate.net
… A differential risk for disease development was associated with … with chronic beryllium
disease contributes to persistentsusceptibility to beryllium sensitization and chronic beryllium

Immunologic effects of beryllium exposure

AP Fontenot - Annals of the American Thoracic Society, 2018 - atsjournals.org
… leads to the development of chronic beryllium disease. After … contribute to the eradication
of beryllium-induced disease … epitopes: susceptibility and progression markers for beryllium

[HTML][HTML] Genomic biomarkers in chronic beryllium disease and sarcoidosis

NW Lin, LA Maier, MM Mroz, S Jacobson… - Respiratory …, 2021 - Elsevier
… We hypothesized that differential expression of these genes … Both have genetic and
environmental contributions, as well as … on genetic susceptibility with HLA-DPB1 Glu 69 being the …

[HTML][HTML] Adaptive immunity in pulmonary sarcoidosis and chronic beryllium disease

SA Greaves, SM Atif, AP Fontenot - Frontiers in immunology, 2020 - frontiersin.org
… immune-mediated diseases, disease susceptibility in CBD and … many of these diseases are
similar, the differential diagnosis is … that contributes to disease development and progression. …

Lack of an exposure response and interaction with HLA-DPβ1 and DRβ1 polymorphisms in the development of beryllium toxicity in a high beryllium exposure cohort

V Widyaningsih, K Rosenman, MJ Reilly… - … of Occupational and …, 2020 - journals.lww.com
… influence the development of chronic beryllium disease (CBD) … metrics (ie, peak) and
HLA-DPB1 Glu69 and other genetic … at facility B likely contributed to the different exposure levels, …

Chronic beryllium disease: update on a moving target

MG MacMurdo, MM Mroz, DA Culver, RA Dweik… - Chest, 2020 - Elsevier
beryllium in 1971, our understanding of the risks of beryllium sensitization and chronic beryllium
disease (… in late 2018 reduced the PEL for beryllium, increased requirements for medical …

[HTML][HTML] Chronic beryllium disease (berylliosis)

LS Newman, LA Maier - Waltham (MA): UpToDate, 2021 - medilib.ir
… both beryllium exposure and HLA-DPB1 genotype contributeDIFFERENTIAL DIAGNOSIS
— The differential diagnosis of … Interestingly, the three patients with Glu69 homozygosity (…