[HTML][HTML] Mitochondrial pharmacology of dimebon (latrepirdine) calls for a new look at its possible therapeutic potential in Alzheimer's disease
SH Eckert, J Gaca, N Kolesova, K Friedland… - Aging and …, 2018 - ncbi.nlm.nih.gov
… a transgenic mouse model expressing high ß-amyloid levels … but also in mouse cortex,
hippocampus and somewhat less the … indicating that dimebon restores changes of mitochondrial …
hippocampus and somewhat less the … indicating that dimebon restores changes of mitochondrial …
New therapeutic property of Dimebon as a neuroprotective agent
A Ustyugov, E Shevtsova, GM Ashraf… - Current Medicinal …, 2018 - ingentaconnect.com
… Dimebon on formation of pathological protein deposits by examining the disease pattern
development and changes in transgenic mice … level in primary rat hippocampal cells as well as …
development and changes in transgenic mice … level in primary rat hippocampal cells as well as …
[PDF][PDF] Gene dosage determines the behavioural phenotype in the 5xFAD mouse model of Alzheimer's disease: analysis of the contribution of brain insulin signalling …
D Medina-Vera, EN Zambrana-Infantes… - 2022 - scholar.archive.org
… HTZ and HZ mice exhibited hippocampal impairment caused … that amyloid plaques are
deposited in the hippocampal … mouse models, such as 3xTg-AD, which exhibited changes …
deposited in the hippocampal … mouse models, such as 3xTg-AD, which exhibited changes …
[HTML][HTML] Rodent models of amyloid-beta feature of Alzheimer's disease: Development and potential treatment implications
… : APP and PS1 genes, a 3xTg-AD mouse model was generated to … ) failed to alter hippocampal
BDNF levels in mice, but this … Drugs, such as Latrepirdine (Dimebon), which was shown to …
BDNF levels in mice, but this … Drugs, such as Latrepirdine (Dimebon), which was shown to …
A bird's-eye view of the multiple biochemical mechanisms that propel pathology of Alzheimer's disease: recent advances and mechanistic perspectives on how to halt …
C Vegh, K Stokes, D Ma, D Wear… - Journal of …, 2019 - content.iospress.com
… levels of hippocampal TFEB and progress of AD pathology [43]. A … models of mice experience
behavioral changes as well with … that treatment of dimebon in AD transgenic mice lead to a …
behavioral changes as well with … that treatment of dimebon in AD transgenic mice lead to a …
Alzheimer's disease: the role of mitochondrial dysfunction and potential new therapies
ZL Hawking - Bioscience Horizons: The International Journal of …, 2016 - academic.oup.com
… for some of the classic pathological changes observed in … only been conducted in transgenic
mouse models and C elegans, … When dimebon was compared to a placebo group over a 6-…
mouse models and C elegans, … When dimebon was compared to a placebo group over a 6-…
[HTML][HTML] Impaired autophagy in amyloid-beta pathology: A traditional review of recent Alzheimer's research
M Yuan, Y Wang, Z Huang, F Jing, P Qiao… - Journal of Biomedical …, 2023 - ncbi.nlm.nih.gov
… The major pathological changes in AD progression are the … before extracellular amyloid
deposition in five AD mice models [77… , but is activated in the hippocampus in AD patients. ErbB2 …
deposition in five AD mice models [77… , but is activated in the hippocampus in AD patients. ErbB2 …
[PDF][PDF] Characterization of the new htau-KI mouse model for Alzheimer's disease with a focus on the role of immune cells during progressing cerebral amyloidosis
S Barendrecht - 2021 - opendata.uni-halle.de
… LTP in the CA1 region of the hippocampus at 8 months of age. ...… to pathological changes in
the central nervous system (CNS) … pathology under progressing amyloid pathology in htau-KI …
the central nervous system (CNS) … pathology under progressing amyloid pathology in htau-KI …
Indolylazine derivative induces chaperone expression in aged neural cells and prevents the progression of Alzheimer's disease
VF Lazarev, EA Dutysheva, ER Mikhaylova… - Molecules, 2022 - mdpi.com
… ageing due to the significant changes in the glutathione redox … to reveal that 3xTg-AD and
Tg-APP/PS1 mice were much less … containing Aβ42 in the mouse hippocampus, we used the …
Tg-APP/PS1 mice were much less … containing Aβ42 in the mouse hippocampus, we used the …
Novel therapeutic strategies for dementia
R Cacabelos, C Torrellas, I Carrera… - CNS & Neurological …, 2016 - ingentaconnect.com
… and recognition memory in 3XTg-AD mice. Nobiletin reduced … hippocampus of 3XTg-AD as
well as wild-type mice [130]. … Catalpol reversed all these neurochemical changes, indicating …
well as wild-type mice [130]. … Catalpol reversed all these neurochemical changes, indicating …