… of superantigens, how they directly interact with immune … the crosslinking of T-cell receptors
(TCRs) Vβ with MHC class II α 1 … T-cell superantigens first bind to MHC Class II receptors and …

… of noncanonical T cell subsets such as mucosal-associated … , including positions that are
not directly contacting Ag. For … Furthermore, secreted Abs can form structures with up to 12 …

… of the GPCR class C family of the calcium-sensing receptor (… In our experience, the T cell
response to superantigens does … directly binds superantigens and bridges the superantigens …

… ) secretion in a murine CD3ζ and FcR-γ-deficient αβ T cell line… T cells, CD4 binds to MHC
class II and CD8 to MHC class I. … murine G8 γδ TCR, Abs that directly bind to CD3ε (UCHT-1 in …

… Engagement of TCR by pMHC, superantigen, or monoclonal … , like polarized secretion of
cytokines or cytotoxic granules. … than in the CDR loops directly contacting the pMHC surface (42)…

… SAgs activate T cells by direct binding and crosslinking of the … T cell superantigens (SAgs)
are a family of potent, secreted, … interactions between T cell receptor (TCR) and MHC class II (…

… , T cell receptor (TCR… bind directly to germline-encoded regions of Vγ4, specifically the
CDR2 and HV4 loops 54 (Figure 2B), in a manner similar to superantigen binding to TCRβ chains…

… β-chain variable (TRBV) regions of αβ T cell receptors (TCRs). … These effects are induced
mechanistically via direct cross-… that recombinant SpeC did not induce the secretion of IL-2 from …

… signals via the gamma-delta T-cell receptor), Wilhelm-Sander-… γδ T-cell subsets, 1-3 the
increasing knowledge on γδ T-cell … γ-chain analogous to binding of some superantigens to the …

… Bacterial superantigens are potent virulence factors secreted by … superantigens bind
directly as intact proteins to most major histocompatibility class II (MHC-II) and T-cell receptor …