… that MHC products can directly bind to protein Ag–derived … SAg, they rapidly proliferate and
secrete cytokines, after which … MHC class II isotypes and allotypes but that SAg-induced T cell …

… Superantigens (SAgs) are microbial proteins that have the … Interleukin-2 (IL-2)–secreting
CD4 T cells facilitate CD8 T-cell … , the class II invariant chain complex can be directly sorted into …

… to the variable β-chain of the T cell receptor (TcRVβ). Currently, … pyogenes SAgs are generally
secreted in only small amounts… antibody for binding to CD28 without directly binding to the …

… of the T cell receptors and outside of the peptide-binding groove of a class II major …
directly measures the thermodynamics of binding but can also estimate the stoichiometry of …

… binding site and is therefore unlikely to directly affect binding … as common anchor points for
superantigens in general, we … complex with a human T cell receptor, performed computational …

… 100,000 CCRF-CEM T-cell at a ratio of 1/20, the secretion of IL-… binds directly to the
alpha-helical chain of the MHC class II, … that measuring superantigenic activities that stimulate …

… protein degradation by the cytoplasmic proteasome [56], or … that directly engage various
natural killer (NK) receptors (such … included in complexes with MHC or superantigen ligands. …

… Type I toxins secreted by Staphylococcus aureus are the … of SEB and SEA to directly bind
the surface of primary CD4 + T … To verify whether SEB and SEA binding to the T cell surface …

… directly via the TCR. Indeed, TCR V γ 9 V δ 2–mediated γδ … cells (a human TCR-deficient T
cell line that can be used to assay … l1l6 cells elicited IL-2 secretion as well as moderate TCR …

… of toxins secreted by this organism, known as superantigens (… expression of specific Vβ
T-cell receptors, we hypothesized … Antibody titers were determined by direct ELISA against 1 µg …