[HTML][HTML] SARS-CoV-2 spike does not possess intrinsic superantigen-like inflammatory activity

C Amormino, V Tedeschi, G Paldino, S Arcieri… - Cells, 2022 - mdpi.com
… of T cells with a T-cell receptor variable β chain (TCRVβ) … significant change in the secretion
of inflammatory cytokines … has been recently associated with three HLA class I alleles (A02, …

The role of HLA-class I heavy-chain interactions with killer-cell immunoglobulin-like receptors in immune regulation

S Kollnberger - Critical Reviews™ in Immunology, 2016 - dl.begellhouse.com
… , and peptides designed for recognition by T-cell receptors (… of the B27 heavy chains,
which is predicted to directly contact … controls in response to superantigen stimulation.Moreover, …

[HTML][HTML] Enhanced interaction between SEC2 mutant and TCR Vβ induces MHC II–independent activation of T cells via PKCθ/NF-κB and IL-2R/STAT5 signaling …

X Fu, M Xu, Y Song, Y Li, H Zhang, J Zhang… - Journal of Biological …, 2018 - ASBMB
… complex class II (MHC II)-dependent T-cell mitogen, binds MHC II and T-cell receptor (TCR) …
Regulation of superantigen-induced T cell activation in the absence and the presence of …

Blocking Superantigen‐Mediated Diseases: Challenges and Future Trends

P Wang, Z Fredj, H Zhang, G Rong… - Journal of …, 2024 - Wiley Online Library
Superantigens are virulence factors secreted by … processing and the T-cell receptor (TCR)
Vβ-chain, resulting … by APCs but directly bind to the MHC II antigen-binding domain and the …

[HTML][HTML] Single-molecule, super-resolution, and functional analysis of G protein-coupled receptor behavior within the T cell immunological synapse

JH Felce, L Parolini, E Sezgin, PF Céspedes… - Frontiers in cell and …, 2021 - frontiersin.org
… of T cells through interaction of T cell receptors (TCRs) with … distribution within the synapse
of direct T cell-APC interactions. … independent of active secretion into the synapse by the APC. …

[PDF][PDF] Effect of Superantigen on Detecting Group A Streptococcus Specific T cell responses

T Olanrewaju - 2023 - research-information.bris.ac.uk
… Each T cell expresses a unique T cell receptor (TCR) … tissue T cells respond by secreting
a variety of inflammatory … in GAS and how they affect particular cell populations will direct

[HTML][HTML] Bacterial deception of MAIT cells in a cloud of superantigen and cytokines

JK Sandberg, A Norrby-Teglund, E Leeansyah - PLoS Biology, 2017 - journals.plos.org
… the normally highly stringent T-cell receptor antigen specificity to … SAgs are potent bacterial
exotoxins secreted by bacteria … They bind directly to major histocompatibility complex class II …

Stimulation Strength Determined by Superantigen Dose Controls Subcellular Localization of FOXP3 Isoforms and Suppressive Function of CD4+ CD25+ FOXP3+ T …

J Lee, N Park, M Nicosia, JY Park… - The Journal of …, 2024 - journals.aai.org
Superantigens (SAgs) are potent T cell stimulants that bind directly to the V region of a subset
of b-chains … A quantitative real time PCR method to analyze T cell receptor Vbeta subgroup …

Superantigen as a Promising Immunotherapy Treatment against Cancer: A Review Article

SH Al Zahrani, S El Hadad - European Online Journal of …, 2022 - european-science.com
… complex class II molecules and T cell receptors and form a tri… -binding site is found in most
SAgs, and it has a direct effect … cal changes start in the cytoplasmic region of the CD3 complex …

[HTML][HTML] Staphylococcal superantigens spark host-mediated danger signals

T Krakauer, K Pradhan, BG Stiles - Frontiers in immunology, 2016 - frontiersin.org
bind directly to specific Vβ regions of T-cell receptors (TCR) and major histocompatibility
complex (MHC) class II … synthesize less IL-2 but still secrete IFNγ that can mediate toxic shock …