… A variety of folate receptor targeting constructs have been developed against FRα-… of
response to FRα-targeted therapies. These folic acid-based targeting methodologies can also be …

… either chemotherapeutics for therapeutic or prosthetic groups for imaging purposes have been
… Almost all folic acid-based chemotherapeutic drugs and radiopharmaceuticals have been …

… for the selective delivery of imaging and therapeutic agents to target cells, such as … targeting
ligand, folic acid has several advantages such as 1) high affinity to its target, folate receptors …

… The discovery of folic acid is the result of hard work of Lucy Wills, a medical researcher
graduating from Cambridge University with the degree of botanist and geologist. In 1930, she …

… discovery of the high-affinity, high-specificity folate receptor … Vintafolide is one such folate
receptor targeted therapy, it is a … of folate receptor targeted therapies in development are the …

… -targeted delivery, which proved significant targeting efficacy. As a result of this strategy,
various folic acid-based small … properties weren't discovered until the middle of the 20th century. …

… We also discuss the criteria for selecting the optimal therapeutic drug payload, spacer and
… Finally, we review the folate receptor targeting SMDCs that are in preclinical development …

… Tc]EC20, a folate receptor targeting imaging agent that has … treatment with folate receptor
targeted small-molecule drug conjugates (SMDCs) such as vintafolide [25, 26]. A PET imaging …

… had about molecular mechanisms involved in cancer development, the more useful tools we
… /folate receptor, one of the most important ligand-receptor interactions used to target cancer. …

… A particularly promising target for selective targeting are the folate receptors (FR) that are
often over-expressed on cancer cells. Here, we report on a conjugate of the pentadentate …