… to enhance the inhibitory effects. Here we will review the … of Dyn A analogs at the BRs have
discovered a lead ligand, (… induced neuroexcitatory effects and attenuate hyperalgesic effects …

… effects via opioid receptors with a preference for the kappa receptor but also neuroexcitatory
effects, which cause hyperalgesia. We have shown that the neuroexcitatory effects are …

… also known to have neuroexcitatory effects in the spinal cord … degradation, while retaining
the amphipathic nature of the ligand… This finding indicates that modification on the third position …

… , causing hyperalgesia, a neuroexcitatory effect [79]. The affinity … actual biological roles and
discover new formulations that … Dynorphin A analogs for the treatment of chronic neuropathic …

… Dynorphin A (Dyn A) is the endogenous opioid peptide for … Peptidomimetic enkephalin
analogues previously developed in … To our knowledge, this finding is first of its class for the opioid …

… of amphipathic non-opioid dynorphin A analogues for rat … Our approach to the drug discovery
process starts with the … ) inhibitor, H89, could inhibit DYN A’s neuroexcitatory effects and …

… N-terminus does not fully suppress biological activity while … and prominent place in drug
discovery research, OXA is an … would be helpful to designing analogs that can be used to …

… spinal delivery of dynorphin causes an analogous profile of … the role of dynorphinergic
inhibitory interneurons in the SDH … by the finding that minocycline, an inhibitor of microglia …

… Since the first discovery of enkephalin, approximately a dozen … -2 analogs were synthesized
to investigate the effect of ring … Porcine pituitary dynorphin: complete amino acid sequence …

… Enzyme immunoassay for dynorphin protein levels in Sp5C ....… Expression of Pdyn
gene and dynorphin A peptide increased … how specific excitation or inhibition of dynorphin-expressing …