… , and microglia, with neurons under physiological conditions. … disrupt glial function, and how
this disruption might impair glia-neuron metabolic crosstalk and ultimately promote cognitive …

… dysfunctional energy metabolism (compromised mitochondrial ATP production), amyloid-β
generation, endothelial dysfunction, and blood–brain-barrier disruption… metabolic dysfunction …

… -neuron lactate shuttle (ANLS), interrupt the balance in energy metabolism, and resulting in
cognitive function, … against the disorder of energy metabolism caused by aluminum in mice. …

… Brain energy metabolism declines subtly during ageing and this … Local interneuron dysfunction
disrupts synchronization between remote neuronal networks and across brain regions 31,…

… disturbed GLUT1 expression and metabolic shifts toward glucose dependency. The sustained
hyper-activation of PFKFB3 (master regulator of glycolysis) and PDK1 (primary inhibitor of …

… tivity and behavioral deficits in LgDel mice. Our results provide new mechanistic insight
and a potential therapeutic approach for disrupted cortical circuit development in 22q11DS. …

… , and on its neurodegenerative-related disruption. We sought … to increased vulnerability
to cognitive decline. Thus, in light … of vulnerable neuronal circuits in AD [205]. Mitochondrial …

… metabolic conditions show MCI to be more similar to AD than to the declined cognitive function
… This contributes to explaining the cognitive impairment in the MCI subjects in the current …

… cognitive consequences of disrupted energy metabolism. Thus “bioenergetic stress” drives
systemic inflammation-induced dysfunction. … LPS-induced cognitive impairment in ME7 mice …

… the cognitive decline associated with brain aging and neurodegenerative disorders like AD.
… ], and (c) H 2 O 2 disrupts the glutathione transferase-JNK complex and releases the latter […